1649-18-9
Chemical Structure
Azaperone
Synonym(s): R-1929
- CAS No.: 1649-18-9
- Formula:C19H22FN3O
- Molecular Weight:327.40
IUPAC Name: 1-(4-fluorophenyl)-4-(4-(pyridin-2-yl)piperazin-1-yl)butan-1-one
InChIKey: XTKDAFGWCDAMPY-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(F)C=C1)CCCN2CCN(C3=NC=CC=C3)CC2
Biological Activity: Azaperone is an antagonist of dopamine D2 receptor (Dopamine D2 Receptor) and α-adrenergic receptor (AR). Azaperone reduces vasomotor tone, mean arterial pressure, hematocrit, hemoglobin concentration, and etorphine-induced duration; induces transient tachycardia followed by bradycardia, splenic uptake of red blood cells, and sedation; alters animal behaviors; and produces sedation with distinct onset and duration in foals. Azaperone is used for sedation and tranquilization in various animals to reduce stress and aggressive behaviors, and serves as a preanesthetic agent[1][2][3].
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Azaperone | 99.23% | Azaperone is an antagonist of dopamine D2 receptor (Dopamine D2 Receptor) and α-adrenergic receptor (AR). Azaperone reduces vasomotor tone, mean arterial pressure, hematocrit, hemoglobin concentration, and etorphine-induced duration; induces transient tachycardia followed by bradycardia, splenic uptake of red blood cells, and sedation; alters animal behaviors; and produces sedation with distinct onset and duration in foals. Azaperone is used for sedation and tranquilization in various animals to reduce stress and aggressive behaviors, and serves as a preanesthetic agent. | ||||||||||||||||||||
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Azaperone (Standard) | ≥98% | Azaperone (R-1929) (Standard) is the analytical standard of Azaperone (HY-B1470). This product is intended for research and analytical applications. Azaperone is an antagonist of dopamine D2 receptor (Dopamine D2 Receptor) and α-adrenergic receptor (AR). Azaperone reduces vasomotor tone, mean arterial pressure, hematocrit, hemoglobin concentration, and etorphine-induced duration; induces transient tachycardia followed by bradycardia, splenic uptake of red blood cells, and sedation; alters animal behaviors; and produces sedation with distinct onset and duration in foals. Azaperone is used for sedation and tranquilization in various animals to reduce stress and aggressive behaviors, and serves as a preanesthetic agent. | ||||||||||||||||||||
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Azaperone-d4 | 95.83% | Azaperone-d4 (R-1929-d4) is the deuterium labeled Azaperone (HY-B1470). Azaperone is an antagonist of dopamine D2 receptor (Dopamine D2 Receptor) and α-adrenergic receptor (AR). Azaperone reduces vasomotor tone, mean arterial pressure, hematocrit, hemoglobin concentration, and etorphine-induced duration; induces transient tachycardia followed by bradycardia, splenic uptake of red blood cells, and sedation; alters animal behaviors; and produces sedation with distinct onset and duration in foals. Azaperone is used for sedation and tranquilization in various animals to reduce stress and aggressive behaviors, and serves as a preanesthetic agent. | ||||||||||||||||||||
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References
- [1]. Lees P, et al. Effects of azaperone on cardiovascular and respiratory functions in the horse. Br J Pharmacol. 1976;56(3):263-269. [Content Brief]
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[2]. Buss P, et al. Effect of Azaperone on Induction Times in Etorphine-Immobilized White Rhinoceros (Ceratotherium simum). J Wildl Dis. 2022 Jan 1;58(1):245-247.
[Content Brief] - [3]. Svoboda M, et al. Efficacy of the intranasal application of azaperone for sedation in weaned piglets. Vet Med (Praha). 2023;68(4):145-151. Published 2023 Apr 26. [Content Brief]
