Cinuperone
Cinuperone is a multi-target competitive receptor ligand and σ receptor antagonist that acts on Dopamine D1, σ, Dopamine D1, and 5-HT2 receptors. Cinuperone shows significantly higher affinity for σ receptors than for Dopamine D1 receptors, and only exhibits moderate binding activity for dopamine D2 receptors. Cinuperone can be used in the research of central nervous system diseases.
For research use only. We do not sell to patients.
- CAS No.: 82117-51-9
- Formula: C23H24FN3O
- Molecular Weight:377.46
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All Sigma Receptor Isoforms
MoreAll Dopamine Receptor Isoforms
MoreAll 5-HT Receptor Isoforms
More
Biological Activity
|
D2 Receptor 75 nM (IC50) |
D1 Receptor 6200 nM (IC50) |
5-HT2 Receptor 240 nM (IC50) |
Cinuperone potently inhibits [3H]-spiperone binding to dopamine2 receptors in rat striatal membranes with an IC50 of 76 nM[2].
Cinuperone weakly inhibits [3H]-SCH 23390 binding to dopamine1 receptors in rat striatal membranes with an IC50 of 6200 nM[2].
Cinuperone potently inhibits [3H]-haloperidol binding to σ receptors in rat cerebellar membranes with an IC50 of 54 nM[2].
Cinuperone moderately inhibits [3H]-ketanserin binding to 5-HT2 receptors in rat frontal cortex membranes with an IC50 of 240 nM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Cinuperone (10 μmol/kg; administered 30 minutes prior to apomorphine) antagonizes apomorphine-induced climbing in male albino mice with an ED50 of 10 μmol/kg[2].
Cinuperone (15 μmol/kg; administered 30 minutes prior to apomorphine) antagonizes apomorphine-induced yawning in male albino rats with an ED50 of 15 μmol/kg[2].
Cinuperone (0.97 μmol/kg; i.p.; administered 30 minutes prior to quipazine) antagonizes quipazine-induced head twitches in male albino rats with an ED50 of 0.97 μmol/kg[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 82117-51-9
-
Molecular Weight 377.46
-
Formula C23H24FN3O
-
SMILES
O=C(C1=CC=C(F)C=C1)CCCN2CCN(C=3N=CC4=CC=CC=C4C3)CC2
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cinuperone Related Classifications
HY-W754019 Related Classifications
Powered by Bioz