173531-58-3
Chemical Structure
Naphthoquine phosphate
- CAS No.: 173531-58-3
- Formula:C24H34ClN3O9P2
- Molecular Weight:605.94
IUPAC Name: 2-((tert-butylamino)methyl)-4-((7-chloroquinolin-4-yl)amino)-5,6,7,8-tetrahydronaphthalen-1-ol bis(phosphate)
InChIKey: QTYPWHKJEDCDNH-UHFFFAOYSA-N
SMILES: ClC1=CC=C(C(NC2=C(CCCC3)C3=C(O)C(CNC(C)(C)C)=C2)=CC=N4)C4=C1.O=P(O)(O)O.O=P(O)(O)O
Biological Activity: Naphthoquine phosphate is an orally active antimalarial and antiviral agent. Naphthoquine phosphate exhibits ex vivo activity against multidrug-resistant Plasmodium falciparum and Plasmodium vivax, preferentially targeting ring-stage rather than trophozoite-stage parasites. Naphthoquine phosphate inhibits coronavirus (SARS-CoV-2, HCoV-OC43, HCoV-229E) replication by affecting viral entry and post-entry replication. Naphthoquine phosphate is used for research on malaria and Covid-19[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Naphthoquine phosphate | 99.33% | Naphthoquine phosphate is an orally active antimalarial and antiviral agent. Naphthoquine phosphate exhibits ex vivo activity against multidrug-resistant Plasmodium falciparum and Plasmodium vivax, preferentially targeting ring-stage rather than trophozoite-stage parasites. Naphthoquine phosphate inhibits coronavirus (SARS-CoV-2, HCoV-OC43, HCoV-229E) replication by affecting viral entry and post-entry replication. Naphthoquine phosphate is used for research on malaria and Covid-19. | ||||||||||||||||||||
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References
- [1]. Xie Y, et al. The gender-related variability in the pharmacokinetics and antiplasmodial activity of naphthoquine in rodents. Malaria journal. 2020 Feb 13;19(1):71.
- [2]. Wirjanata G, et al. Potent Ex Vivo Activity of Naphthoquine and Methylene Blue against Drug-Resistant Clinical Isolates of Plasmodium falciparum and Plasmodium vivax. Antimicrobial agents and chemotherapy. 2015 Oct;59(10):6117-24.
- [3]. Song Y, et al. Naphthoquine: A Potent Broad-Spectrum Anti-Coronavirus Drug In Vitro. Molecules (Basel, Switzerland). 2022 Jan 21;27(3):712.
