18683-91-5
18683-91-5
Chemical Structure
Ambroxol
Synonym(s): NA-872
- CAS No.: 18683-91-5
- Formula:C13H18Br2N2O
- Molecular Weight:378.10
IUPAC Name: (1r,4r)-4-((2-amino-3,5-dibromobenzyl)amino)cyclohexan-1-ol
InChIKey: JBDGDEWWOUBZPM-XYPYZODXSA-N
SMILES: O[C@H]1CC[C@H](NCC2=CC(Br)=CC(Br)=C2N)CC1
Biological Activity: Ambroxol (NA-872), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research[1][2].
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Ambroxol | 99.88% | Ambroxol (NA-872), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research. | ||||||||||||||||||||
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Ambroxol (Standard) | ≥98% | Ambroxol (Standard) is the analytical standard of Ambroxol. This product is intended for research and analytical applications. Ambroxol (NA-872), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research. | ||||||||||||||||||||
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Ambroxol-d5 | Ambroxol-d5 (NA-872-d5) is deuterium labeled Ambroxol. Ambroxol (NA-872), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research. | |||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.98
HY-B1039ARAmbroxol hydrochloride (Standard) -
Similarity Score 0.73
HY-B0372Bromhexine -
Similarity Score 0.73
HY-B0372ABromhexine hydrochloride -
Similarity Score 0.69
HY-B1039ASAmbroxol-d5 hydrochloride -
Similarity Score 0.66
HY-W130058trans-4-(6,8-Dibromo-1,2-dihydroquinazolin-3(4H)-yl)cyclohexanol hydrochloride -
Similarity Score 0.65
HY-117406Clencyclohexerol -
Similarity Score 0.61
HY-165407Neltenexine -
Similarity Score 0.58
HY-156328NSC 48160 -
Similarity Score 0.56
HY-131145RBrombuterol hydrochloride (Standard) -
Explore the MedChemAI to find more analogs
References
- [1]. Vojo Deretic, et al. Enhancement of lung levels of antibiotics by ambroxol and bromhexine. Expert Opin Drug Metab Toxicol. 2019 Mar;15(3):213-218. [Content Brief]
- [2]. Anna Migdalska-Richards, et al. Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice. Ann Neurol. 2016 Nov;80(5):766-775. [Content Brief]
