2124-57-4
2124-57-4
Chemical Structure
Menaquinone-7
Synonym(s): Vitamin K2-7; Vitamin K2(35); Vitamin MK-7
- No. CAS: 2124-57-4
- Formula:C46H64O2
- Molecular Weight:649.00
IUPAC Name: 2-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-3-methylnaphthalene-1,4-dione
InChIKey: RAKQPZMEYJZGPI-LJWNYQGCSA-N
SMILES: O=C1C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C)=C(C)C(C2=C1C=CC=C2)=O
Biological Activity: Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs (orally active), is originally discovered as the anti-hemorrhagic factors. Menaquinone-7 inhibits osteoclast bone resorption in vitro and stimulates bone formation in femoral tissue of aged female rats. Menaquinone-7 has a well-researched potential in the prevention of aging-induced bone degeneration. Menaquinone-7 is also a pharmacological option for activating Gla matrix protein and intervening in the progression of calcific aortic stenosis (CAVS)[1][2][3][4][5].
| Referencia número | Nombre del producto | Pureza | Descripciòn | Pricing | |||||||||||||||||||
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Menaquinone-7 | 98.51% | Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs (orally active), is originally discovered as the anti-hemorrhagic factors. Menaquinone-7 inhibits osteoclast bone resorption in vitro and stimulates bone formation in femoral tissue of aged female rats. Menaquinone-7 has a well-researched potential in the prevention of aging-induced bone degeneration. Menaquinone-7 is also a pharmacological option for activating Gla matrix protein and intervening in the progression of calcific aortic stenosis (CAVS). | ||||||||||||||||||||
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Menaquinone-7 (Standard) | 98.27% | Menaquinone-7 (Standard) is the analytical standard of Menaquinone-7. This product is intended for research and analytical applications. Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs (orally active), is originally discovered as the anti-hemorrhagic factors. Menaquinone-7 inhibits osteoclast bone resorption in vitro and stimulates bone formation in femoral tissue of aged female rats. Menaquinone-7 has a well-researched potential in the prevention of aging-induced bone degeneration. Menaquinone-7 is also a pharmacological option for activating Gla matrix protein and intervening in the progression of calcific aortic stenosis (CAVS). | ||||||||||||||||||||
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Menaquinone-7-d7 | Menaquinone-7-d7 is the deuterium labeled Menaquinone-7. Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs, is originally discovered as the anti-hemorrhagic factors. Menaquinone-7 (Vitamin K2-7) is identified as the most bioactive cofactor for the carboxylation reaction of Gla-proteins . Supplementation with Menaquinone-7 (Vitamin K2-7) is a pharmacological option for activating matrix Gla protein and intervening in the progression of calcific aortic valve stenosis (CAVS). | |||||||||||||||||||||
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Menaquinone-7-13C6 | 96.0% | Menaquinone-7-13C6 is the 13C-labeled Menaquinone-7. Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs, is originally discovered as the anti-hemorrhagic factors. Menaquinone-7 (Vitamin K2-7) is identified as the most bioactive cofactor for the carboxylation reaction of Gla-proteins . Supplementation with Menaquinone-7 (Vitamin K2-7) is a pharmacological option for activating matrix Gla protein and intervening in the progression of calcific aortic valve stenosis (CAVS). | ||||||||||||||||||||
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Menaquinone 9 (Standard) | 97.88% | Menaquinone 9 (Standard) is the analytical standard of Menaquinone 9 (HY-131501). This product is intended for research and analytical applications. Menaquinone 9 is a naphthoquinone-type vitamin K and electron transport component produced by bacteria. Menaquinone 9 is an orally active analog of Vitamin K2 (HY-109569). Menaquinone 9 acts as an ultraviolet-sensitive, photooxidizable substrate that generates more polar photodegradation products under oxygen and ultraviolet irradiation. Menaquinone 9 binds to the αβ dimer of Escherichia coli nitrate reductase, supporting electron transport within the αβ subunit structure of the enzyme. Menaquinone 9 serves as a precursor for bone Menaquinone-4 (HY-B2156). Menaquinone 9 can be used in studies related to metabolic diseases. | ||||||||||||||||||||
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Vitamin K2(5) | Vitamin K2(5) is an isoprenyl homologue of the Vitamin K2 (HY-109569) series. Vitamin K2(5) occurs in the heartwood of Tabebuia avellanedae. | |||||||||||||||||||||
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Menaquinone 6 | 98.0% | Menaquinone 6 is a active product found in Wolinella succinogenes. Menaquinone 6 is a form of vitamin K2 (HY-109569) that has antimicrobial activity. | ||||||||||||||||||||
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SARS-CoV-2-IN-66 | SARS-CoV-2-IN-66 (1), a vitaminK derivative, is a SARS-CoV-2 inhibitor, with an EC50 of 70.8 μM in VeroE6/TMPRSS2 cells. | |||||||||||||||||||||
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Menaquinone-4 | 99.96% | Menaquinone-4 is a vitamin K, used as a hemostatic agent, and also a adjunctive therapy for the pain of osteoporosis. | ||||||||||||||||||||
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Menaquinone-4-13C6 | Menaquinone-4-13C6 is the 13C-labeled Menaquinone-4. Menaquinone-4 is a vitamin K, used as a hemostatic agent, and also a adjunctive therapy for the pain of osteoporosis. | |||||||||||||||||||||
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cis-Vitamin K1 | cis-Vitamin K1 (cis-Phylloquinone; cis-Phytomenadione) is an isomer of Vitamin K1 (HY-N0684) that can be used for the synthesis of Vitamin K1 (HY-N0684). | |||||||||||||||||||||
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(Rac)-Vitamin K1 | (Rac)-Vitamin K1 ((Rac)-Phylloquinone; (Rac)-Phytomenadione) is a vitamin (phylloquinone) found in Urtica dioica that targets angiotensin-converting enzyme 2 (ACE-2). (Rac)-Vitamin K1 can be used in studies related to coronavirus disease 2019 (COVID-19). | |||||||||||||||||||||
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Vitamin K1 (Standard) | 97.72% | Vitamin K1 (Standard) is the analytical standard of Vitamin K1. This product is intended for research and analytical applications. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism. | ||||||||||||||||||||
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References
- [1]. Yamaguchi M, et al. Inhibitory effect of menaquinone-7 (vitamin K2) on osteoclast-like cell formation and osteoclastic bone resorption in rat bone tissues in vitro. Mol Cell Biochem. 2001 Dec;228(1-2):39-47. [Content Brief]
- [2]. Katsuyama H, et al. Menaquinone-7 regulates gene expression in osteoblastic MC3T3E1 cells. Int J Mol Med. 2007 Feb;19(2):279-84. [Content Brief]
- [3]. Yamaguchi M, et al. Stimulatory effect of menaquinone-7 on bone formation in elderly female rat femoral tissues in vitro: prevention of bone deterioration with aging. Int J Mol Med. 2002 Dec;10(6):729-33. [Content Brief]
- [4]. Peeters FECM, et al. Bicuspid Aortic Valve Stenosis and the Effect of Vitamin K2 on Calcification Using 18F-Sodium Fluoride Positron Emission Tomography/Magnetic Resonance: The BASIK2 Rationale and Trial Design. Nutrients. 2018 Mar 21;10(4):386. [Content Brief]
- [5]. Yamaguchi M, Taguchi H, Gao YH, Igarashi A, Tsukamoto Y. Effect of vitamin K2 (menaquinone-7) in fermented soybean (natto) on bone loss in ovariectomized rats. J Bone Miner Metab. 1999;17(1):23-9. [Content Brief]
