2149-70-4
Chemical Structure
NG-nitro-L-arginine
Synonym(s): Nω-nitro-L-arginine; L-NOARG; L-NG-Nitroarginine
- CAS No.: 2149-70-4
- Formula:C6H13N5O4
- Molecular Weight:219.20
IUPAC Name: Nw-nitro-L-arginine
InChIKey: MRAUNPAHJZDYCK-BYPYZUCNSA-N
SMILES: N[C@@H](CCCNC(N[N+]([O-])=O)=N)C(O)=O
Biological Activity: NG-nitro-L-arginine (Nω-nitro-L-arginine; L-NOARG; L-NG-Nitroarginine) is a nitric oxide synthase (NO Synthase) inhibitor, with a Kd of 15 nM for constitutive NOS from bovine brain and a Ki of 4.4 μM for inducible NOS from mouse macrophages. NG-nitro-L-arginine competitively blocks the synthesis of NO from L-arginine; in addition, it inhibits endothelium-dependent vasodilation, and exhibits effects such as blood pressure elevation, heart rate reduction and vasoconstriction. NG-nitro-L-arginine regulates mitochondrial respiratory efficiency, antioxidant enzyme activity, lipid peroxidation level and tissue lead content in rats. NG-nitro-L-arginine can be used in studies related to cardiovascular diseases[1][2][3].
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NG-nitro-L-arginine | 99.78% | NG-nitro-L-arginine (Nω-nitro-L-arginine; L-NOARG; L-NG-Nitroarginine) is a nitric oxide synthase (NO Synthase) inhibitor, with a Kd of 15 nM for constitutive NOS from bovine brain and a Ki of 4.4 μM for inducible NOS from mouse macrophages. NG-nitro-L-arginine competitively blocks the synthesis of NO from L-arginine; in addition, it inhibits endothelium-dependent vasodilation, and exhibits effects such as blood pressure elevation, heart rate reduction and vasoconstriction. NG-nitro-L-arginine regulates mitochondrial respiratory efficiency, antioxidant enzyme activity, lipid peroxidation level and tissue lead content in rats. NG-nitro-L-arginine can be used in studies related to cardiovascular diseases. | ||||||||||||||||||||
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- [1]. Molnár M, et al. Nω‑Nitro‑L‑arginine, an inhibitor of nitric oxide synthesis, increases blood pressure in rats and reverses the pregnancy‑induced refractoriness to vasopressor agents. American Journal of Obstetrics and Gynecology, 1992, 166(5): 1560‑1567.
- [2]. Tkaczenko H, et al. Elucidation of the Role of L‑Arginine and Nω‑Nitro‑L‑Arginine in the Treatment of Rats with Different Levels of Hypoxic Tolerance and Exposure to Lead Nitrate. Cellular Physiology & Biochemistry, 2024.
- [3]. Furfine ES, et al. Selective inhibition of constitutive nitric oxide synthase by L-NG-nitroarginine. Biochemistry. 1993 Aug 24;32(33):8512-7. [Content Brief]
Keywords
