2170551-59-2
Chemical Structure
VU6008055
Synonym(s): AF98943
- CAS No.: 2170551-59-2
- Formula:C20H21N5OS
- Molecular Weight:379.48
InChIKey: ZWNZWHFKGJDMCH-UHFFFAOYSA-N
SMILES: CC1=NN=C(SC2=C3N=CN=C2NCC4=CC=C(C(C)(O)C)C=C4)C3=C1C
Biological Activity: VU6008055 (AF98943) is a brain-penetrant, orally active and selective muscarinic acetylcholine receptor subtype 4 (mAChR4) activator with human EC50 values of 73.4 nM. VU6008055 potentiates mAChR4 receptor activity in the presence of acetylcholine, and exhibits no activity at mAChR1, mAChR3, or mAChR5. VU6008055 can be used for the research of schizophrenia, parkinson’s disease, alzheimer’s disease[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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VU6008055 | 99.43% | VU6008055 (AF98943) is a brain-penetrant, orally active and selective muscarinic acetylcholine receptor subtype 4 (mAChR4) activator with human EC50 values of 73.4 nM. VU6008055 potentiates mAChR4 receptor activity in the presence of acetylcholine, and exhibits no activity at mAChR1, mAChR3, or mAChR5. VU6008055 can be used for the research of schizophrenia, parkinson’s disease, alzheimer’s disease. | ||||||||||||||||||||
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- [1]. Engers JL, et al. Discovery of Pre-Clinical Candidate VU6008055/AF98943: A Highly Selective, Orally Bioavailable, and Structurally Distinct Tricyclic M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) with Robust In Vivo Efficacy. ACS Chem Neurosci. 2025;16(11):2141-2162. [Content Brief]
Keywords
