222551-17-9
Chemical Structure
Adoprazine
Synonym(s): SLV313
- CAS No.: 222551-17-9
- Formula:C24H24FN3O2
- Molecular Weight:405.46
IUPAC Name: 1-(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)-4-((5-(4-fluorophenyl)pyridin-3-yl)methyl)piperazine
InChIKey: IUVSEUFHPNITEQ-UHFFFAOYSA-N
SMILES: FC1=CC=C(C2=CN=CC(CN3CCN(C4=C5OCCOC5=CC=C4)CC3)=C2)C=C1
Biological Activity: Adoprazine (SLV313) is a full 5-HT1A receptor agonist with a pEC50 of 9 at cloned h5-HT1A receptors. Adoprazine (SLV313) is a full D2 and D3 receptor antagonist with pA2s of 9.3 and 8.9 at hD2 and hD3 receptors, respectively. Adoprazine (SLV313) has the characteristics of atypical antipsychotics[1].
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Adoprazine | 98.60% | Adoprazine (SLV313) is a full 5-HT1A receptor agonist with a pEC50 of 9 at cloned h5-HT1A receptors. Adoprazine (SLV313) is a full D2 and D3 receptor antagonist with pA2s of 9.3 and 8.9 at hD2 and hD3 receptors, respectively. Adoprazine (SLV313) has the characteristics of atypical antipsychotics. | ||||||||||||||||||||
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Similarity Score 0.99
HY-14782AAdoprazine hydrochloride -
Similarity Score 0.59
HY-105328S-14489 -
Similarity Score 0.58
HY-182584S 15931 -
Similarity Score 0.57
HY-121653Flesinoxan -
Similarity Score 0.57
HY-121653BFlesinoxan hydrochloride -
Similarity Score 0.56
HY-116076S-15535 -
Similarity Score 0.55
HY-133832Elopiprazole -
Similarity Score 0.55
HY-19742ALecozotan hydrochloride -
Similarity Score 0.54
HY-100820BSarizotan dihydrochloride -
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References
- [1]. Andrew C McCreary, et al. SLV313 (1-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-4- [5-(4-fluoro-phenyl)-pyridin-3-ylmethyl]-piperazine monohydrochloride): a novel dopamine D2 receptor antagonist and 5-HT1A receptor agonist potential antipsychotic drug. Neuropsychopharmacology. 2007 Jan;32(1):78-94. [Content Brief]
