Lecozotan hydrochloride
Based on 1 Customer Validation
Lecozotan (SRA-333) hydrochloride is an orally active and selective antagonist of 5-HT1A with a Ki of 4.5 nM for cloned human 5-HT1A receptor. Lecozotan hydrochloride enhances the stimulated release of glutamate and acetylcholine in the hippocampus and possesses cognitive-enhancing properties. Lecozotan hydrochloride has the potential for mild-to-moderate Alzheimer's disease (AD) research.
For research use only. We do not sell to patients.
- Purity: 99.04%
- CAS No.: 433282-68-9
- Formula: C28H30ClN5O3
- Molecular Weight:520.02
-
Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Bioactive Compound Library Max
HY-L181
-
Bioactive Compound Library
HY-L001
-
GPCR/G Protein Compound Library
HY-L006
-
Neuronal Signaling Compound Library
HY-L013
-
Clinical Compound Library
HY-L026
-
Drug Repurposing Compound Library
HY-L035
-
Orally Active Compound Library
HY-L061
-
Neurotransmitter Receptor Compound Library
HY-L062
-
Anti-Alzheimer's Disease Compound Library
HY-L069
-
Anti-Parkinson's Disease Compound Library
HY-L085
-
Neurodegenerative Disease-related Compound Library
HY-L086
-
5-HT Receptor Compound Library
HY-L121
-
Coagulation and Anti-coagulation Compound Library
HY-L136
-
Membrane Protein-targeted Compound Library
HY-L149
-
Membrane Receptor-targeted Compound Library
HY-L150
-
Highly Selective Inhibitors Library
HY-L158
-
Multi-Target Compound Library
HY-L176
-
MCE Bioactive Compound Library
HY-L001V
-
Drug Repurposing Compound Library Plus
HY-L035P
-
Clinical Compound Library Plus
HY-L026P
-
High-Throughput Bioactive Compound Library
HY-L205
-
Lactylation Compound Library
HY-L249
All 5-HT Receptor Isoforms
More
Biological Activity
|
5-HT1A Receptor |
5-HT1A Receptor 4.5 nM (Ki) |
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
CAS No. 433282-68-9
-
Appearance Solid
-
Molecular Weight 520.02
-
Formula C28H30ClN5O3
-
Color Off-white to light yellow
-
SMILES
O=C(C1=CC=C(C=C1)C#N)N(C2=CC=CC=N2)C[C@H](N3CCN(CC3)C4=C5C(OCCO5)=CC=C4)C.Cl
-
Synonyms
SRA-333 hydrochloride
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 125 mg/mL (240.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (274 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
[1]. L E Schechter, et al. Lecozotan (SRA-333): a selective serotonin 1A receptor antagonist that enhances the stimulated release of glutamate and acetylcholine in the hippocampus and possesses cognitive-enhancing properties. J Pharmacol Exp Ther. 2005 Sep;314(3):1274-89. [Content Brief]
[2]. Alain Patat, et al. Safety, tolerability, pharmacokinetics and pharmacodynamics of ascending single and multiple doses of lecozotan in healthy young and elderly subjects. Br J Clin Pharmacol. 2009 Mar;67(3):299-308. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9230 mL | 9.6150 mL | 19.2300 mL | 48.0751 mL |
| 5 mM | 0.3846 mL | 1.9230 mL | 3.8460 mL | 9.6150 mL | |
| 10 mM | 0.1923 mL | 0.9615 mL | 1.9230 mL | 4.8075 mL | |
| 15 mM | 0.1282 mL | 0.6410 mL | 1.2820 mL | 3.2050 mL | |
| 20 mM | 0.0962 mL | 0.4808 mL | 0.9615 mL | 2.4038 mL | |
| 25 mM | 0.0769 mL | 0.3846 mL | 0.7692 mL | 1.9230 mL | |
| 30 mM | 0.0641 mL | 0.3205 mL | 0.6410 mL | 1.6025 mL | |
| 40 mM | 0.0481 mL | 0.2404 mL | 0.4808 mL | 1.2019 mL | |
| 50 mM | 0.0385 mL | 0.1923 mL | 0.3846 mL | 0.9615 mL | |
| 60 mM | 0.0321 mL | 0.1603 mL | 0.3205 mL | 0.8013 mL | |
| 80 mM | 0.0240 mL | 0.1202 mL | 0.2404 mL | 0.6009 mL | |
| 100 mM | 0.0192 mL | 0.0962 mL | 0.1923 mL | 0.4808 mL |
Lecozotan hydrochloride Related Classifications
HY-19742A Related Classifications
Powered by Bioz