2292115-41-2
2292115-41-2
Chemical Structure
PF-4211
- CAS No.: 2292115-41-2
- Formula:C17H13N3O2
- Molecular Weight:291.30
IUPAC Name: 4-(4-(1-methyl-1H-pyrazol-5-yl)phenoxy)furo[3,2-c]pyridine
InChIKey: ZYVVTSUQLCQHJC-UHFFFAOYSA-N
SMILES: CN1N=CC=C1C2=CC=C(C=C2)OC3=NC=CC4=C3C=CO4
Biological Activity: PF-4211 is a selective non-catechol D1R agonist with a Ki value of 2.2 μM.. PF-4211 activates adenylate cyclase by binding to D1R, thereby increasing intracellular cAMP levels. PF-4211 can be used in research related to Parkinson's disease and schizophrenia[1][2].
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PF-4211 | PF-4211 is a selective non-catechol D1R agonist with a Ki value of 2.2 μM.. PF-4211 activates adenylate cyclase by binding to D1R, thereby increasing intracellular cAMP levels. PF-4211 can be used in research related to Parkinson's disease and schizophrenia. | |||||||||||||||||||||
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References
- [1]. Davoren JE, et al. Discovery and Lead Optimization of Atropisomer D1 Agonists with Reduced Desensitization. Journal of medicinal chemistry. 2018 Dec 27;61(24):11384-11397. [Content Brief]
- [2]. Gray DL, et al. Impaired β-arrestin recruitment and reduced desensitization by non-catechol agonists of the D1 dopamine receptor. Nature communications. 2018 Feb 14;9(1):674. [Content Brief]
