2375432-47-4
Chemical Structure
MS4322
Synonym(s): YS43-22
- CAS No.: 2375432-47-4
- Formula:C55H76N10O12S
- Molecular Weight:1101.32
IUPAC Name: N-((S)-3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-((1-((S)-19-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidine-1-carbonyl)-20,20-dimethyl-17-oxo-3,6,9,12,15-pentaoxa-18-azahenicosanoyl)azetidin-3-yl)amino)pyrimidine-4-carboxamide
InChIKey: XUJMNOQMXWVXQE-STHBVIMFSA-N
SMILES: O=C(C1=NC=NC(NC2CN(C(COCCOCCOCCOCCOCC(N[C@H](C(N3[C@H](C(N[C@H](C4=CC=C(C5=C(C)N=CS5)C=C4)C)=O)C[C@@H](O)C3)=O)C(C)(C)C)=O)=O)C2)=C1)NC[C@H](O)CN6CC7=C(C=CC=C7)CC6
Biological Activity:
MS4322 (YS43-22) is a specific PRMT5 PROTAC degrader. MS4322 reduces the PRMT5 protein level with a DC50 of 1.1 μM in MCF-7 cells. MS4322 inhibits the methyltransferase activity of PRMT5 with an IC50 of 18 nM. MS4322 promotes ubiquitination and degradation of PRMT5. MS4322 can be used for the research of breast cancer, lung cancer, and hepatocellular cancer. (Pink: PRMT5 ligand (HY-173092); Blue: E3 ligase ligand HY-112078); Black: linker (HY-124780); E3+linker (HY-173093 ))[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MS4322 | 99.14% | MS4322 (YS43-22) is a specific PRMT5 PROTAC degrader. MS4322 reduces the PRMT5 protein level with a DC50 of 1.1 μM in MCF-7 cells. MS4322 inhibits the methyltransferase activity of PRMT5 with an IC50 of 18 nM. MS4322 promotes ubiquitination and degradation of PRMT5. MS4322 can be used for the research of breast cancer, lung cancer, and hepatocellular cancer. (Pink: PRMT5 ligand (HY-173092); Blue: E3 ligase ligand HY-112078); Black: linker (HY-124780); E3+linker (HY-173093 )). |
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-
Similarity Score 1.00
HY-141877BMS4322 (isomer) -
Similarity Score 0.78
HY-173561MS115 -
Similarity Score 0.76
HY-173561AMS115 TFA -
Similarity Score 0.64
HY-162537LYP-8 -
Similarity Score 0.63
HY-161180Antitumor agent-136 -
Similarity Score 0.63
HY-173093Me-(S,R,S)-AHPC-CO-CH2-PEG4-O-CH2-COOH -
Similarity Score 0.62
HY-136001PROTAC α-synuclein degrader 3 -
Similarity Score 0.62
HY-111593Homo-PROTAC pVHL30 degrader 1 -
Similarity Score 0.62
HY-136257CMP98 -
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