252017-04-2
252017-04-2
Chemical Structure
AZD7545
- CAS No.: 252017-04-2
- Formula:C19H18ClF3N2O5S
- Molecular Weight:478.87
IUPAC Name: (R)-4-((3-chloro-4-(3,3,3-trifluoro-2-hydroxy-2-methylpropanamido)phenyl)sulfonyl)-N,N-dimethylbenzamide
InChIKey: DTDZLJHKVNTQGZ-GOSISDBHSA-N
SMILES: O=C(N(C)C)C1=CC=C(S(=O)(C2=CC=C(NC([C@@](C)(O)C(F)(F)F)=O)C(Cl)=C2)=O)C=C1
Biological Activity: AZD7545 is a potent, competitive, selective PDHK2 (pyruvate dehydrogenase kinase 2) inhibitor with IC50s of 36.8 nM, 6.4 nM for PDHK1 and PDHK2, respectively[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AZD7545 | 99.91% | AZD7545 is a potent, competitive, selective PDHK2 (pyruvate dehydrogenase kinase 2) inhibitor with IC50s of 36.8 nM, 6.4 nM for PDHK1 and PDHK2, respectively. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.86
HY-184945PDK ligand-1 -
Similarity Score 0.63
HY-101256ZM226600 -
Similarity Score 0.55
HY-19185ZD-6169 -
Similarity Score 0.53
HY-B1377Acedapsone -
Similarity Score 0.52
HY-W0087154,4'-Sulfonyldibenzoic acid -
Similarity Score 0.52
HY-107574TC-E 5003 -
Similarity Score 0.52
HY-W1074664-((4-((4-Aminophenyl)sulfonyl)phenyl)amino)-4-oxobutanoic acid -
Similarity Score 0.51
HY-108250(R)-Bicalutamide -
Similarity Score 0.51
HY-14249Bicalutamide -
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