2557349-50-3
2557349-50-3
Chemical Structure
NP3-253
- CAS No.: 2557349-50-3
- Formula:C19H23F3N4O
- Molecular Weight:380.41
InChIKey: UVVZGYXCKGWWCC-CQSZACIVSA-N
SMILES: CC1=CC(C(F)(F)F)=CC(O)=C1C2=NN=C(N[C@@H]3CCCN(CC)C3)C=C2
Biological Activity: NP3-253 is an orally active and brain-penetranted NLRP3 inflammasome inhibitor. NP3-253 functions as a molecular glue that prevents NACHT-subdomain rearrangements, locking NLRP3 in an inactive conformation. NP3-253 inhibits production of pro-inflammatory cytokines IL-1β and IL-18. NP3-253 can be used for the research of inflammation and neurological disease, suah as peritonitis[1].
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NP3-253 | 99.78% | NP3-253 is an orally active and brain-penetranted NLRP3 inflammasome inhibitor. NP3-253 functions as a molecular glue that prevents NACHT-subdomain rearrangements, locking NLRP3 in an inactive conformation. NP3-253 inhibits production of pro-inflammatory cytokines IL-1β and IL-18. NP3-253 can be used for the research of inflammation and neurological disease, suah as peritonitis. | ||||||||||||||||||||
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References
Keywords
