2749283-47-2
2749283-47-2
Chemical Structure
Losartan carboxylic acid-d9
Synonym(s): E-3174-d9; EXP-3174-d9
- CAS No.: 2749283-47-2
- Formula:C22H12D9ClN6O2
- Molecular Weight:445.95
IUPAC Name: 3-chloro-2-hydroxypropyl benzoate
InChIKey: ZEUXAIYYDDCIRX-WRMMWXQOSA-N
SMILES: [2H]C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C1=NC(Cl)=C(C(O)=O)N1CC2=CC=C(C3=C(C4=NN=NN4)C=CC=C3)C=C2
Biological Activity: EXP3174-d9 is the deuterium labeled EXP3174[1].
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Losartan carboxylic acid-d9 | EXP3174-d9 is the deuterium labeled EXP3174. | |||||||||||||||||||||
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Losartan Carboxylic Acid (Standard) | ≥98% | Losartan Carboxylic Acid (Standard) is the analytical standard of Losartan Carboxylic Acid. This product is intended for research and analytical applications. Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure. | ||||||||||||||||||||
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Losartan-d4 (carboxylic acid) | 98.09% | Losartan-d4 carboxylic acid (E-3174-d4) is the deuterium labeled Losartan Carboxylic Acid (HY-12765). Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure. | ||||||||||||||||||||
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Losartan carboxylic acid-d4 hydrochloride | Losartan carboxylic acid-d4 (hydrochloride) is deuterium labeled Losartan Carboxylic Acid. Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure. | |||||||||||||||||||||
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Losartan-d3 Carboxylic Acid | Losartan-d3 Carboxylic Acid is the deuterium labeled Losartan. Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM. | |||||||||||||||||||||
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Losartan Carboxylic Acid | 99.47% | Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure. | ||||||||||||||||||||
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