2756-87-8
2756-87-8
Chemical Structure
Monomethyl fumarate
- CAS No.: 2756-87-8
- Formula:C5H6O4
- Molecular Weight:130.10
IUPAC Name: (E)-4-methoxy-4-oxobut-2-enoic acid
InChIKey: NKHAVTQWNUWKEO-NSCUHMNNSA-N
SMILES: O=C(OC)/C=C/C(O)=O
Biological Activity: Monomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease[1][2][3].
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Monomethyl fumarate | 99.95% | Monomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease. | ||||||||||||||||||||
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Monomethyl fumarate (Standard) | ≥98% | Monomethyl fumarate (Standard) is the analytical standard of Monomethyl fumarate. This product is intended for research and analytical applications. Monomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease. | ||||||||||||||||||||
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Monomethyl fumarate-d2 | 98.19% | Monomethyl fumarate-d2 is a deuterium labeled Monomethyl fumarate (HY-103252). Monomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF) (HY-17363), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease. | ||||||||||||||||||||
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Monomethyl fumarate-d3 | 99.01% | Monomethyl fumarate-d3 is a deuterium labeled Monomethyl fumarate (HY-103252). Monomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF) (HY-17363), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease. | ||||||||||||||||||||
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Monomethyl fumarate-d5 | Monomethyl fumarate-d5 is deuterium labeled Monomethyl fumarate (HY-103252). Monomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF) (HY-17363), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease. | |||||||||||||||||||||
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Structural Analogs
-
Similarity Score 1.00
HY-W705769(Z)-4-(Methoxy-d3)-4-oxobut-2-enoic acid -
Similarity Score 0.87
HY-W019696Monoethyl fumarate -
Similarity Score 0.87
HY-W704787Monoethyl fumarate-d5 -
Similarity Score 0.86
HY-W392912AMethyl trans-4-oxo-2-pentenoate -
Similarity Score 0.86
HY-W127447Maleate trihydrate sodium -
Similarity Score 0.84
HY-17363Dimethyl fumarate -
Similarity Score 0.82
HY-W015883RFumaric acid (Standard) -
Similarity Score 0.82
HY-W015883SFumaric acid-13C4 -
Similarity Score 0.82
HY-W015883S1Fumaric acid-13C2 -
Explore the MedChemAI to find more analogs
References
- [1]. Tang H, et al. The psoriasis drug monomethylfumarate is a potent nicotinic acid receptor agonist. Biochem Biophys Res Commun. 2008 Oct 31;375(4):562-5. [Content Brief]
- [2]. Jiang D, et al. Monomethyl Fumarate Protects the Retina From Light-Induced Retinopathy. Invest Ophthalmol Vis Sci. 2019 Mar 1;60(4):1275-1285. [Content Brief]
- [3]. Sghaier R, et al. Dimethyl fumarate and monomethyl fumarate attenuate oxidative stress and mitochondrialalterations leading to oxiapoptophagy in 158N murine oligodendrocytes treated with 7β-hydroxycholesterol. J Steroid Biochem Mol Biol. 2019 Nov;194:105432. [Content Brief]
