3010261-70-5
Chemical Structure
HDAC6-IN-89
- CAS No.: 3010261-70-5
- Formula:C28H35N11O4S2
- Molecular Weight:653.78
InChIKey: LMYSESMAORELDI-UHFFFAOYSA-N
SMILES: O=C(NC1=NN=C(NC2CCN(C3=NN=C(NC(C4=CN(CCCCCCC(NO)=O)N=C4)=O)S3)CC2)S1)CC5=CC=CC=C5
Biological Activity: HDAC6-IN-89 is a selective HDAC6 inhibitor (IC50 values of 0.003, 0.031, 0.039, 0.046, 0.050, 0.057, and 3.30 μM for HDAC6, HDAC1, HDAC3, HDAC2, HDAC8, HDAC10, and GLS1, respectively). HDAC6-IN-89 increases Histone/Tubulin acetylation and blocks glutaminase-mediated conversion of glutamine to glutamate and glutamine metabolism. HDAC6-IN-89 induces ROS, Apoptosis, and cell cycle arrest. HDAC6-IN-89 exhibits anticancer activity against lung cancer, prostate cancer, and colon cancer[1].
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HDAC6-IN-89 | HDAC6-IN-89 is a selective HDAC6 inhibitor (IC50 values of 0.003, 0.031, 0.039, 0.046, 0.050, 0.057, and 3.30 μM for HDAC6, HDAC1, HDAC3, HDAC2, HDAC8, HDAC10, and GLS1, respectively). HDAC6-IN-89 increases Histone/Tubulin acetylation and blocks glutaminase-mediated conversion of glutamine to glutamate and glutamine metabolism. HDAC6-IN-89 induces ROS, Apoptosis, and cell cycle arrest. HDAC6-IN-89 exhibits anticancer activity against lung cancer, prostate cancer, and colon cancer. | |||||||||||||||||||||
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