3035173-63-5
3035173-63-5
Chemical Structure
HDAC-IN-49
- CAS No.: 3035173-63-5
- Formula:C26H27FN4O4
- Molecular Weight:478.52
IUPAC Name: 5-bromopyridin-3,4,6-d3-2-amine
InChIKey: GBIQEYYBFBGNOZ-UHFFFAOYSA-N
SMILES: O=C(NO)C1=CC=C(CN(CC(NCC2=CC=CC=C2)=O)C(C3=CC=C(N(C)C)C=C3)=O)C(F)=C1
Biological Activity: HDAC-IN-49 is a potent unselective HDAC (HDAC) inhibitor with IC50s of 13 nM, 14 nM, 21 nM, 1880 nM, and 10 nM for HDAC1, HDAC2, HDAC3, HDAC4, and HDAC6. HDAC-IN-49 demonstrates prominent antileukemic activity with low cytotoxic activity toward healthy cells[1].
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HDAC-IN-49 | HDAC-IN-49 is a potent unselective HDAC (HDAC) inhibitor with IC50s of 13 nM, 14 nM, 21 nM, 1880 nM, and 10 nM for HDAC1, HDAC2, HDAC3, HDAC4, and HDAC6. HDAC-IN-49 demonstrates prominent antileukemic activity with low cytotoxic activity toward healthy cells. | |||||||||||||||||||||
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References
Keywords
