3037596-35-0
3037596-35-0
Chemical Structure
STAT3-IN-15
- CAS No.: 3037596-35-0
- Formula:C20H17F3N2O3S
- Molecular Weight:422.42
IUPAC Name: (Z)-2-(2,4-dihydroxybenzylidene)-7-hydroxybenzofuran-3(2H)-one
InChIKey: MSOPUAJZYRMAJX-UHFFFAOYSA-N
SMILES: O=C(N1CCN(CC1)CC2=CC(F)=C(C=C2F)F)C3=CC4=CC=CC=C4S3(=O)=O
Biological Activity: STAT3-IN-15 is a potent and orally active STAT3 inhibitor against idiopathic pulmonary fibrosis (IPF). STAT3-IN-15 inhibits STAT3 phosphorylation. STAT3-IN-15 also inhibits the migration and deformation of epithelial cells induced by TGF-β1 and inhibit epithelial-mesenchymal transition (EMT)[1].
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STAT3-IN-15 | 98.99% | STAT3-IN-15 is a potent and orally active STAT3 inhibitor against idiopathic pulmonary fibrosis (IPF). STAT3-IN-15 inhibits STAT3 phosphorylation. STAT3-IN-15 also inhibits the migration and deformation of epithelial cells induced by TGF-β1 and inhibit epithelial-mesenchymal transition (EMT). | ||||||||||||||||||||
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STAT3-IN-39 | STAT3-IN-39 (compound 10K) is an orally active STAT3 inhibitor that exhibits excellent inhibitory activity against STAT3 phosphorylation, with an IC50 of 0.47 μM in NIH-3T3 cells. STAT3-IN-39 inhibits the TGF-β1-induced fibrotic response and blocks the epithelial-mesenchymal transition in A549. STAT3-IN-39 can be utilized in research related to idiopathic pulmonary fibrosis. | |||||||||||||||||||||
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References
Keywords
