MARY15
Based on 1 Customer Validation
MARY15 is a pyridinylpiperazine-based derivative of MARY1. MARY15 activates uncoupled mitochondrial respiration and upregulates p-AKT (S473) phosphorylation in renal proximal tubule cells.
For research use only. We do not sell to patients.
- Purity : 99.97%
- CAS No.: 3107758-65-3
- Formula: C19H18F3N3O2
- Molecular Weight:377.36
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
MARY15 (30 nM; 24 h) activates uncoupled mitochondrial respiration in renal proximal tubule cells, as measured by FCCP-OCR[1].
MARY15 (30 nM; 1 h) upregulates p-AKT (S473) phosphorylation in renal proximal tubule cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Renal proximal tubule cells (RPTCs)
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Concentration:30 nM
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Incubation Time:1 h
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Result:Significantly increased phosphorylation levels of AKT at Ser473.
Chemical Information
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CAS No. 3107758-65-3
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Appearance Solid
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Molecular Weight 377.36
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Formula C19H18F3N3O2
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Color White to off-white
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SMILES
O=C(NC1=CC=CC(C(N2CCN(C)CC2)=O)=C1)C3=C(F)C=C(F)C=C3F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (132.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6500 mL | 13.2499 mL | 26.4999 mL | 66.2497 mL |
| 5 mM | 0.5300 mL | 2.6500 mL | 5.3000 mL | 13.2499 mL | |
| 10 mM | 0.2650 mL | 1.3250 mL | 2.6500 mL | 6.6250 mL | |
| 15 mM | 0.1767 mL | 0.8833 mL | 1.7667 mL | 4.4166 mL | |
| 20 mM | 0.1325 mL | 0.6625 mL | 1.3250 mL | 3.3125 mL | |
| 25 mM | 0.1060 mL | 0.5300 mL | 1.0600 mL | 2.6500 mL | |
| 30 mM | 0.0883 mL | 0.4417 mL | 0.8833 mL | 2.2083 mL | |
| 40 mM | 0.0662 mL | 0.3312 mL | 0.6625 mL | 1.6562 mL | |
| 50 mM | 0.0530 mL | 0.2650 mL | 0.5300 mL | 1.3250 mL | |
| 60 mM | 0.0442 mL | 0.2208 mL | 0.4417 mL | 1.1042 mL | |
| 80 mM | 0.0331 mL | 0.1656 mL | 0.3312 mL | 0.8281 mL | |
| 100 mM | 0.0265 mL | 0.1325 mL | 0.2650 mL | 0.6625 mL |
MARY15 Related Classifications
HY-17684 Related Classifications
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