307-55-1
Chemical Structure
Perfluorododecanoic acid
Synonym(s): PFDoA
- CAS No.: 307-55-1
- Formula:C12HF23O2
- Molecular Weight:614.10
IUPAC Name: 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,12-tricosafluorododecanoic acid
InChIKey: CXGONMQFMIYUJR-UHFFFAOYSA-N
SMILES: C(=O)(C(C(C(C(C(C(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)O
Biological Activity: Perfluorododecanoic acid (PFDoA) is an orally active, blood-brain barrier-permeable perfluorinated compound. Perfluorododecanoic acid increases Caspase 3 activity, disrupts mitochondrial membrane potential, and elevates ROS levels. Perfluorododecanoic acid induces cognitive deficits. Perfluorododecanoic acid exhibits hepatotoxicity[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Perfluorododecanoic acid | 95% | Perfluorododecanoic acid (PFDoA) is an orally active, blood-brain barrier-permeable perfluorinated compound. Perfluorododecanoic acid increases Caspase 3 activity, disrupts mitochondrial membrane potential, and elevates ROS levels. Perfluorododecanoic acid induces cognitive deficits. Perfluorododecanoic acid exhibits hepatotoxicity. | ||||||||||||||||||||
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- [1]. Liu Y, et al. Induction of time-dependent oxidative stress and related transcriptional effects of perfluorododecanoic acid in zebrafish liver. Aquat Toxicol. 2008;89(4):242-250. [Content Brief]
- [2]. Fang X, et al. Oxidative stress and mitochondrial membrane potential are involved in the cytotoxicity of perfluorododecanoic acid to neurons. Toxicol Ind Health. 2020;36(11):892-897. [Content Brief]
- [3]. Kawabata K, et al. Perfluorododecanoic Acid Induces Cognitive Deficit in Adult Rats. Toxicol Sci. 2017;157(2):421-428. [Content Brief]
Keywords
