307002-71-7
307002-71-7
Chemical Structure
CL-82198
- CAS No.: 307002-71-7
- Formula:C17H22N2O3
- Molecular Weight:302.37
IUPAC Name: N-(4-morpholinobutyl)benzofuran-2-carboxamide
InChIKey: KUJQEQAVMNFFAO-UHFFFAOYSA-N
SMILES: O=C(C1=CC2=CC=CC=C2O1)NCCCCN3CCOCC3
Biological Activity: CL-82198 is a selective inhibitor of MMP-13. CL-82198 binds to the entire S1’ pocket of MMP-13, which is the basis for its selectivity towards MMP-13 and the lack of inhibitory activities against other MMPs[1][2]. CL-82198 is a pharmacologic treatment for preventing osteoarthritis (OA) progression[4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CL-82198 | 99.89% | CL-82198 is a selective inhibitor of MMP-13. CL-82198 binds to the entire S1’ pocket of MMP-13, which is the basis for its selectivity towards MMP-13 and the lack of inhibitory activities against other MMPs. CL-82198 is a pharmacologic treatment for preventing osteoarthritis (OA) progression. | ||||||||||||||||||||
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References
- [1]. Rath T et al. Matrix metalloproteinase-13 is regulated by toll-like receptor-9 in colorectal cancer cells and mediates cellular migration. Oncol Lett. 2011 May;2(3):483-488. [Content Brief]
- [2]. George J, et al. MMP-13 deletion decreases profibrogenic molecules and attenuates N-nitrosodimethylamine-induced liver injury and fibrosis in mice. J Cell Mol Med. 2017 Dec;21(12):3821-3835. [Content Brief]
- [4]. Wang M,et al. MMP13 is a critical target gene during the progression of osteoarthritis. Arthritis Res Ther. 2013 Jan 8;15(1):R5. [Content Brief]
