313552-29-3
313552-29-3
Chemical Structure
BMS-684
- CAS No.: 313552-29-3
- Formula:C27H26N4O3
- Molecular Weight:454.52
InChIKey: XIVOLEKHEMYRBO-UHFFFAOYSA-N
SMILES: CN(C1=CC=CC=C1C(N2CCN(C(C3=CC=CC=C3)C4=CC=CC=C4)CC2)=C5[N+]([O-])=O)C5=O
Biological Activity: BMS-684 is a selective DGKα inhibitor with an IC50 of 15 nM. BMS-684 inhibits DGKα kinase activity with >100-fold selectivity over the related DGK type I family members DGKβ and DGKγ. BMS-684 does not inhibit any of the other seven DGK isozymes[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BMS-684 | 98.52% | BMS-684 is a selective DGKα inhibitor with an IC50 of 15 nM. BMS-684 inhibits DGKα kinase activity with >100-fold selectivity over the related DGK type I family members DGKβ and DGKγ. BMS-684 does not inhibit any of the other seven DGK isozymes. | ||||||||||||||||||||
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Laprafylline | Laprafylline (S 9795), a xanthine derivative, is a bronchodilator. Laprafylline has potent anti-bronchoconstrictive effects, inhibiting action on mast cell degranulation and phosphodiesterase (PDE) activity (IC50 of 6 μM). | |||||||||||||||||||||
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S 1432 | S 1432 is a central nervous system depressant with anticonvulsant and muscle relaxant effects. S 1432 significantly reduces acetylcholine levels in the striatum inhibits convulsions induced by pentylenetetrazol. S 1432 can be used in the development of psychotropic drugs. | |||||||||||||||||||||
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Oxatomide | 98.11% | Oxatomide (KW-4354) is an orally active dual antagonist of the H1-histamine receptor and the P2X7 receptor, as well as an inhibitor of serotonin. Oxatomide possesses antihistaminic, antiallergic and anti-inflammatory activities. Oxatomide can be used in the research of allergic diseases. | ||||||||||||||||||||
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Ropizine | Ropizine (SC 13504) is a benzhydryl piperazine with anticonvulsant properties. | |||||||||||||||||||||
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BMS-496 | 99.72% | BMS-496 is adualDGKα/ζlipid kinase inhibitor, with theIC50of 0.09 (DGKα) and 0.006 μM (DGKζ). | ||||||||||||||||||||
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BMS-502 | 99.31% | BMS-502 (Compound 22) is a potent dual inhibitor of diacylglycerol kinase (DGK) α and ζ with IC50 of 4.6 nM and 2.1 nM. BMS-502 enhanced T cell immune responses in mice. BMS-502 can be used in tumor immunity related research. | ||||||||||||||||||||
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S21-1011 | S21-1011 is a selective inhibitor for butyrylcholinesterase (BChE), with IC50 of 0.059 and 0.162 μM, for eqBChE and hBChE, respectively. S21-1011 exhibits good blood-brain barrier (BBB) permeability and good pharmacokinetic characters. S21-1011 exhibits anti-inflammatory activity through activation of keap1-Nrf2-ARE pathway (EC50 is 23.48 μM for antioxidant element ARE activation), ameliorates cognitive impairment in murine Alzheimer’s disease model. | |||||||||||||||||||||
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Cinnarizine (Standard) | 99.01% | Cinnarizine (Standard) is the analytical standard of Cinnarizine. This product is intended for research and analytical applications. | ||||||||||||||||||||
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Elbanizine | 99.79% | Elbanizine inhibits histamine, bradykinin, histamin-release from rat mast cells (IC50 of 0.26 μM) and the IgE-mediated passive cutaneous anaphylaxis (PCA) reaction. Elbanizine exhibits antiallergic and antiasthmatic in guinea pig model. | ||||||||||||||||||||
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Cetirizine impurity D hydrochloride | Cetirizine impurity D hydrochloride is an impurity of Cetirizine D hydrochloride. | |||||||||||||||||||||
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