3145822-23-4
Chemical Structure
CDK9-IN-54
- CAS No.: 3145822-23-4
- Formula:C25H27FN6O2
- Molecular Weight:462.52
SMILES: FC(C=N1)=C(C2=CN(C(C)C)C(C=C2)=O)N=C1NC3=CC=C4C(NC=C4CN5CCOCC5)=C3
Biological Activity: CDK9-IN-54 is an orally active and selective CDK9 inhibitor (IC50 = 0.9 nM), with IC50 values of 100.3 nM, 45.7 nM, 114.9 nM, 92.1 nM, 5.2 nM, and 9.5 nM against CDK1, CDK2, CDK4, CDK7, CLK1, and ERK7, respectively. CDK9-IN-54 directly binds CDK9/cyclin T1 in live cells and downregulates RNA polymerase II Ser2 phosphorylation. CDK9-IN-54 inhibits tumor cell proliferation, migration, and invasion, induces DNA damage, cell cycle arrest, and apoptosis (apoptosis), and downregulates Mcl-1 and c-Myc. CDK9-IN-54 inhibits the growth of hepatocellular carcinoma xenograft tumors. CDK9-IN-54 can be used for research on hepatocellular carcinoma[1].
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CDK9-IN-54 | CDK9-IN-54 is an orally active and selective CDK9 inhibitor (IC50 = 0.9 nM), with IC50 values of 100.3 nM, 45.7 nM, 114.9 nM, 92.1 nM, 5.2 nM, and 9.5 nM against CDK1, CDK2, CDK4, CDK7, CLK1, and ERK7, respectively. CDK9-IN-54 directly binds CDK9/cyclin T1 in live cells and downregulates RNA polymerase II Ser2 phosphorylation. CDK9-IN-54 inhibits tumor cell proliferation, migration, and invasion, induces DNA damage, cell cycle arrest, and apoptosis (apoptosis), and downregulates Mcl-1 and c-Myc. CDK9-IN-54 inhibits the growth of hepatocellular carcinoma xenograft tumors. CDK9-IN-54 can be used for research on hepatocellular carcinoma. | |||||||||||||||||||||
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