327177-34-4
Chemical Structure
tcY-NH2
Synonym(s): (trans-Cinnamoyl)-YPGKF-NH2
- CAS No.: 327177-34-4
- Formula:C40H49N7O7
- Molecular Weight:739.86
IUPAC Name: (S)-N-(2-(((S)-6-amino-1-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)amino)-1-oxohexan-2-yl)amino)-2-oxoethyl)-1-(cinnamoyl-L-tyrosyl)pyrrolidine-2-carboxamide
InChIKey: XKRAKQXQVIGYQC-PHOSSJRVSA-N
SMILES: OC(C=C1)=CC=C1C[C@H](NC(/C=C/C2=CC=CC=C2)=O)C(N3[C@@H](CCC3)C(NCC(N[C@@H](CCCCN)C(N[C@H](C(N)=O)CC4=CC=CC=C4)=O)=O)=O)=O
Biological Activity: tcY-NH2 ((trans-Cinnamoyl)-YPGKF-NH2) is a potent selective PAR4 antagonist peptide. tcY-NH2 inhibits thrombin- and AY-NH2-induced platelet aggregation and endostatin release, and can be used in the research of inflammation, immunology[1][2][6].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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tcY-NH2 | 99.93% | tcY-NH2 ((trans-Cinnamoyl)-YPGKF-NH2) is a potent selective PAR4 antagonist peptide. tcY-NH2 inhibits thrombin- and AY-NH2-induced platelet aggregation and endostatin release, and can be used in the research of inflammation, immunology. | ||||||||||||||||||||
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References
- [1]. Morley D Hollenberg, et al. Proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo. Br J Pharmacol. 2004 Oct;143(4):443-54. [Content Brief]
- [2]. L Ma, et al. Thrombin-induced platelet endostatin release is blocked by a proteinase activated receptor-4 (PAR4) antagonist. Br J Pharmacol. 2001 Oct;134(4):701-4. [Content Brief]
- [6]. Lindisley F Gomides, et al. Blockade of proteinase-activated receptor 4 inhibits neutrophil recruitment in experimental inflammation in mice. Inflamm Res. 2014 Nov;63(11):935-41. [Content Brief]
