34698-41-4
Chemical Structure
1-Aminoindan
Synonym(s): 1-Indanamine; 2,3-Dihydro-1H-inden-1-amine
- CAS No.: 34698-41-4
- Formula:C9H11N
- Molecular Weight:133.19
IUPAC Name: 2,3-dihydro-1H-inden-1-amine
InChIKey: XJEVHMGJSYVQBQ-UHFFFAOYSA-N
SMILES: NC1C2=C(CC1)C=CC=C2
Biological Activity: 1-Aminoindan (1-Indanamine; 2,3-Dihydro-1H-inden-1-amine) is an α-synuclein (α-synuclein) binder. By binding to α-synuclein, 1-Aminoindan promotes the formation of its neuroprotective "cyclic" conformation, thereby reducing the misfolding and aggregation of α-synuclein. 1-Aminoindan is a metabolite of Rasagiline (HY-14605A). 1-Aminoindan can be used in research related to Parkinson's disease[1][2].
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1-Aminoindan | 99.29% | 1-Aminoindan (1-Indanamine; 2,3-Dihydro-1H-inden-1-amine) is an α-synuclein (α-synuclein) binder. By binding to α-synuclein, 1-Aminoindan promotes the formation of its neuroprotective "cyclic" conformation, thereby reducing the misfolding and aggregation of α-synuclein. 1-Aminoindan is a metabolite of Rasagiline (HY-14605A). 1-Aminoindan can be used in research related to Parkinson's disease. | ||||||||||||||||||||
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References
- [1]. Moser, Brigitte Hope. Photoaffinity labelling of alpha-synuclein using diazirine-functionalized caffeine, nicotine, and 1-aminoindan. Diss. 2020.
- [2]. Jakova E, et al. The Bifunctional Dimer Caffeine-Indan Attenuates α-Synuclein Misfolding, Neurodegeneration and Behavioral Deficits after Chronic Stimulation of Adenosine A1 Receptors. International journal of molecular sciences. 2024 Aug 29;25(17):9386. [Content Brief]
