34810-62-3
34810-62-3
Chemical Structure
4′-Demethylnobiletin
- CAS No.: 34810-62-3
- Formula:C20H20O8
- Molecular Weight:388.37
IUPAC Name: 2-(4-hydroxy-3-methoxyphenyl)-5,6,7,8-tetramethoxy-4H-chromen-4-one
InChIKey: NHMZUDOXUOAEOH-UHFFFAOYSA-N
SMILES: O=C1C=C(C2=CC=C(O)C(OC)=C2)OC3=C(OC)C(OC)=C(OC)C(OC)=C13
Biological Activity: 4′-Demethylnobiletin is a bioactive metabolite that activates the PKA/ERK/CREB signaling pathway, enhances CRE-mediated transcription in hippocampal neurons, and reverses memory impairment associated with NMDA receptor antagonism by stimulating ERK signaling[1].
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4′-Demethylnobiletin | 99.69% | 4′-Demethylnobiletin is a bioactive metabolite that activates the PKA/ERK/CREB signaling pathway, enhances CRE-mediated transcription in hippocampal neurons, and reverses memory impairment associated with NMDA receptor antagonism by stimulating ERK signaling. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.92
HY-N41273'-Demethylnobiletin -
Similarity Score 0.89
HY-N0155Nobiletin -
Similarity Score 0.87
HY-N118148-Methoxycirsilineol -
Similarity Score 0.86
HY-N197807-Hydroxy-5,6,8,3',4'-pentamethoxyflavone -
Similarity Score 0.85
HY-N1942R5-O-Demethylnobiletin (Standard) -
Similarity Score 0.83
HY-N0133RTangeretin (Standard) -
Similarity Score 0.81
HY-1346025'-Methoxynobiletin -
Similarity Score 0.81
HY-N11106Gardenin C -
Similarity Score 0.81
HY-N10078Gardenin D -
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