37589-80-3
37589-80-3
Chemical Structure
GTP-γ-S
Synonym(s): Guanosine 5'-[γ-thio]triphosphate
- CAS No.: 37589-80-3
- Formula:C10H16N5O13P3S
- Molecular Weight:539.25
InChIKey: XOFLBQFBSOEHOG-PXMDKTAGSA-N
SMILES: O[C@H]1[C@@H](O)[C@@H](N2C(NC(N)=NC3=O)=C3N=C2)O[C@H]1COP(O)(OP(OP(S)(O)=O)(O)=O)=O
Biological Activity: GTPγS (Guanosine 5'-[γ-thio]triphosphate) is a G-protein activator that protects proteins from proteolytic degradation, stimulates GLUT4 translocation in a tyrosine kinase-dependent manner, stimulate phospholipases and induce actin polymerization. GTPγS to couple with G- protein α, to study its effect on kinase activity. GTPγS acts as a component of lysis buffer[1][2][3][4].
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GTP-γ-S | GTPγS (Guanosine 5'-[γ-thio]triphosphate) is a G-protein activator that protects proteins from proteolytic degradation, stimulates GLUT4 translocation in a tyrosine kinase-dependent manner, stimulate phospholipases and induce actin polymerization. GTPγS to couple with G- protein α, to study its effect on kinase activity. GTPγS acts as a component of lysis buffer. | |||||||||||||||||||||
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References
- [1]. Julie G Hensler, et al. Differential Regulation of 5-HT1A Receptor-G Protein Interactions in Brain Following Chronic Antidepressant Administration. Neuropsychopharmacology. 2002 May;26(5):565-73. [Content Brief]
- [2]. Li-Bin Liu, et al. Insulin recruits GLUT4 from distinct compartments via distinct traffic pathways with differential microtubule dependence in rat adipocytes. J Biol Chem. 2003 Aug 8;278(32):30157-69. doi: 10.1074/jbc.M301511200. [Content Brief]
- [3]. Xufeng Wu, et al. Rab27a is an essential component of melanosome receptor for myosin Va. Mol Biol Cell. 2002 May;13(5):1735-49. [Content Brief]
- [4]. Pilar Sánchez-Blázquez, et al. Brain-specific Galphaz interacts with Src tyrosine kinase to regulate Mu-opioid receptor-NMDAR signaling pathway. Cell Signal. 2009 Sep;21(9):1444-54. [Content Brief]
