37693-01-9
37693-01-9
Chemical Structure
Clofoctol
- CAS No.: 37693-01-9
- Formula:C21H26Cl2O
- Molecular Weight:365.34
IUPAC Name: 2-(2,4-dichlorobenzyl)-4-(2,4,4-trimethylpentan-2-yl)phenol
InChIKey: HQVZOORKDNCGCK-UHFFFAOYSA-N
SMILES: OC1=CC=C(C(C)(C)CC(C)(C)C)C=C1CC2=CC=C(Cl)C=C2Cl
Biological Activity: Clofoctol is a bacteriostatic antibiotic. Clofoctol is used in the treatment of respiratory tract and ear, nose and throat infections caused by Gram-positive bacteria. Clofoctol is only functional against Gram-positive bacteria and can penetrate into human lung tissue. Clofoctol is also an inhibitor of prostate cancer. Clofoctol has antiviral potency[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Clofoctol | 99.05% | Clofoctol is a bacteriostatic antibiotic. Clofoctol is used in the treatment of respiratory tract and ear, nose and throat infections caused by Gram-positive bacteria. Clofoctol is only functional against Gram-positive bacteria and can penetrate into human lung tissue. Clofoctol is also an inhibitor of prostate cancer. Clofoctol has antiviral potency. | ||||||||||||||||||||
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Clofoctol (Standard) | 98.85% | Clofoctol (Standard) is the analytical standard of Clofoctol. This product is intended for research and analytical applications. Clofoctol is a bacteriostatic antibiotic. Clofoctol is used in the treatment of respiratory tract and ear, nose and throat infections caused by Gram-positive bacteria. Clofoctol is only functional against Gram-positive bacteria and can penetrate into human lung tissue. Clofoctol is also an inhibitor of prostate cancer. Clofoctol has antiviral potency. | ||||||||||||||||||||
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Dichlorophen | 98.55% | Dichlorophen is a chlorophenol antimicrobial agent that can destroy the integrity of microbial cell membranes and interfere with the activity of metabolic enzymes. Dichlorophen can covalently bind to the thiol groups of microbial proteins and has broad-spectrum antibacterial, antifungal and anthelmintic activity. Dichlorophen can be used as an antimicrobial agent in the study of drug-resistant bacterial infections. | ||||||||||||||||||||
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InhA-IN-7 | InhA-IN-7 (Compound 11) is a Triclocan (HY-B1119) derivative with inhibitory activity towards enoyl-acyl carrier protein reductase (InhA) with an IC50 of 96 nM. InhA-IN-7 inhibits proliferations of Mycobacterium tuberculosis wildtype and mutant strains with MICs ranging from 19 to 75 μM. | |||||||||||||||||||||
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4-Chloro-3-(4-ethoxybenzyl)phenol | 98.50% | 4-Chloro-3-(4-ethoxybenzyl)phenol is a drug intermediate for synthesis of various active compounds. | ||||||||||||||||||||
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Broussonin C | Broussonin C is a competitive inhibitor of Tyrosinase that can be isolated from Broussonetia kazinoki. Broussonin C inhibits monophenolase and diphenolase with IC50s of 0.43 and 0.57 μM, respectively. | |||||||||||||||||||||
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4-Octylphenol diethoxylate | 4-Octylphenol diethoxylate (Octoxynol-2) is an endogenous estradiol like endocrine disrupter. 4-Octylphenol diethoxylate is the water contaminant. | |||||||||||||||||||||
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Bisphenol C | 99.57% | Bisphenol C is an estrogen receptor-α (ERα) agonist and an ERβ antagonist, with IC50 values of 2.65 nM for ERα and 1.94 nM for ERβ. Bisphenol C is a material of manufacturing polyester polymers like polycarbonate, is widely used in daily items like water bottles, food packaging, textile and so on. | ||||||||||||||||||||
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4-tert-Octylphenol monoethoxylate | 98.97% | 4-tert-Octylphenol monoethoxylate is an alkylphenolethoxylate (APE) and a degradation product of non-ionic surfactants (such as 4-tert-octylphenol polyethoxylate). 4-tert-Octylphenol monoethoxylate also possesses non-steroidal estrogenic activity. Additionally, 4-tert-Octylphenol monoethoxylate has been found in wastewater effluent. | ||||||||||||||||||||
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3-Chlorobisphenol A | 95.19% | 3-Chlorobisphenol A, a chlorinated derivatives of bisphenol A, is an endocrine-disrupting compound. It binds to estrogen receptors, causing disorders in hormone signaling pathways. Bisphenol A is an industrial chemical used in the production of polycarbonate plastics and epoxy resin. | ||||||||||||||||||||
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4-tert-Octylphenol-diethoxylate-13C6 | 4-tert-Octylphenol-diethoxylate-13C6 is the 13C labeled isotope of 4-tert-Octylphenol-diethoxylate. | |||||||||||||||||||||
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4-tert-Octylphenol monoethoxylate-13C6 | 4-tert-Octylphenol monoethoxylate-13C6 is the 13C labeled isotope of 4-tert-Octylphenol monoethoxylate (HY-W777582). 4-tert-Octylphenol monoethoxylate is an alkylphenolethoxylate (APE) and a degradation product of non-ionic surfactants (such as 4-tert-octylphenol polyethoxylate). 4-tert-Octylphenol monoethoxylate also possesses non-steroidal estrogenic activity. Additionally, 4-tert-Octylphenol monoethoxylate has been found in wastewater effluent. | |||||||||||||||||||||
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References
- [1]. Ghilardi PL, et al. Treatment of ear, nose and throat infections with clofoctol. Drugs Exp Clin Res. 1985;11(11):815-8. [Content Brief]
- [2]. Wang M, et al. Identification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer. Br J Pharmacol. 2014 Oct;171(19):4478-89. [Content Brief]
- [3]. Belouzard S, et al. Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in mice. PLoS Pathog. 2022 May 19;18(5):e1010498. [Content Brief]
