38677-85-9
38677-85-9
Chemical Structure
Flunixin
Synonym(s): Sch 14714
- CAS No.: 38677-85-9
- Formula:C14H11F3N2O2
- Molecular Weight:296.24
IUPAC Name: 2-((2-methyl-3-(trifluoromethyl)phenyl)amino)nicotinic acid
InChIKey: NOOCSNJCXJYGPE-UHFFFAOYSA-N
SMILES: O=C(C1=CC=CN=C1NC2=CC=CC(C(F)(F)F)=C2C)O
Biological Activity: Flunixin is a cyclooxygenase (COX) inhibitor with IC50 values of 0.55 and 3.24 μM for COX-1 and COX-2, respectively. Flunixin shows anti-inflammatory effects[1][2].
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Flunixin | Flunixin is a cyclooxygenase (COX) inhibitor with IC50 values of 0.55 and 3.24 μM for COX-1 and COX-2, respectively. Flunixin shows anti-inflammatory effects. | |||||||||||||||||||||
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Flunixin-d3 | Flunixin-d3 is the deuterium labeled Flunixin. Flunixin Meglumine is a potent inhibitor of COX used as analgesic agent with anti-inflammatory and antipyretic activity. | |||||||||||||||||||||
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References
- [1]. Z Cheng, et al. Measurement of cyclooxygenase inhibition in vivo: a study of two non-steroidal anti-inflammatory drugs in sheep. Inflammation. 1998 Aug;22(4):353-66. [Content Brief]
- [2]. Clare E Bryant, et al. Evaluation of the ability of carprofen and flunixin meglumine to inhibit activation of nuclear factor kappa B. Am J Vet Res. 2003 Feb;64(2):211-5. [Content Brief]
