3952-18-9
3952-18-9
Chemical Structure
Cupressuflavone
- CAS No.: 3952-18-9
- Formula:C30H18O10
- Molecular Weight:538.46
IUPAC Name: 5,5',7,7'-tetrahydroxy-2,2'-bis(4-hydroxyphenyl)-4H,4'H-[8,8'-bichromene]-4,4'-dione
InChIKey: LADPNODMUXOPRG-UHFFFAOYSA-N
SMILES: O=C1C=C(C2=CC=C(O)C=C2)OC3=C(C4=C5C(C(C=C(C6=CC=C(O)C=C6)O5)=O)=C(O)C=C4O)C(O)=CC(O)=C13
Biological Activity: Cupressuflavone is a natural product that can be found in Cupressus macrocarpa. Cupressuflavone exhibits anti-inflammatory and antiulcerogenic activities. Cupressuflavone also show protective effects against CCl4-induced hepato- and nephrotoxicity in mice[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Cupressuflavone | 99.32% | Cupressuflavone is a natural product that can be found in Cupressus macrocarpa. Cupressuflavone exhibits anti-inflammatory and antiulcerogenic activities. Cupressuflavone also show protective effects against CCl4-induced hepato- and nephrotoxicity in mice. | ||||||||||||||||||||
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Agathisflavone | 99.33% | Agathisflavone is a flavonoid with antioxidant, anti-inflammatory, antiviral, antiparasitic, cytotoxic, neuroprotective, and hepatoprotective activities. Agathisflavone can improve tissue repair in a spinal cord injury model in rats. | ||||||||||||||||||||
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Sequoiaflavone | Sequoiaflavone is a biflavonoid compound with multiple activities. Sequoiaflavone suppresses hepatic CYP1A1/(7-Ethoxycoumarin O-deethylase) ECOD, prevents Aβ1-42 fibrillization (IC50 = 0.29 μM) and disaggregates amyloid fibrils (EC50 = 2.04 μM), inhibits Alternaria alternata and inhibits human recombinant PDE5A1 overexpressed in COS-7 cells (IC50 = 19.9 μM) to exert NO-independent vasodilation. Sequoiaflavone can be used in Alzheimer's disease, peripheral circulatory disorder, and antifungal research. | |||||||||||||||||||||
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Amentoflavone (Standard) | ≥98% | Amentoflavone (Standard) is the analytical standard of Amentoflavone. This product is intended for research and analytical applications. Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase. | ||||||||||||||||||||
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Ginkgetin (Standard) | ≥98% | Ginkgetin (Standard) is the analytical standard of Ginkgetin. This product is intended for research and analytical applications. Ginkgetin, a biflavone, is isolated from Ginkgo biloba leaves. Ginkgetin exhibit anti-tumor, anti-inflammatory, neuroprotective, anti-fungal activities. Ginkgetin is also a potent inhibitor of Wnt signaling, with an IC50 of 5.92 μΜ. | ||||||||||||||||||||
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Podocarpusflavone B | Podocarpusflavone B is a bisflavone that can be isolated from Padocarpus macraphylla. | |||||||||||||||||||||
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3,8''-Biapigenin | 99.0% | 3,8''-Biapigenin is a biflavone in Hypericum perforatum L.. | ||||||||||||||||||||
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4',4'''-Di-O-methylcupressuflavone | 4',4'''-Di-O-methylcupressuflavone can be isolated from Phyllanthus sellmianus. | |||||||||||||||||||||
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Bilobetin | 99.71% | Bilobetin, an active component of Ginkgo biloba, can reduce blood lipids and improve the effects of insulin. Bilobetin ameliorated insulin resistance, increased the hepatic uptake and oxidation of lipids, reduced very-low-density lipoprotein triglyceride secretion and blood triglyceride levels, enhanced the expression and activity of enzymes involved in β-oxidation and attenuated the accumulation of triglycerides and their metabolites in tissues. Bilobetin also increased the phosphorylation, nuclear translocation and activity of PPARα accompanied by elevated cAMP level and PKA activity. | ||||||||||||||||||||
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Podocarpusflavone A | 99.62% | Podocarpusflavone A is a biflavonoid present in the leaves of Podocarpus henkelii, with anti-tumor, topoisomerase I inhibitory, antibacterial and antifungal activities. Podocarpusflavone A exhibits antibacterial activity against Enterococcus faecalis and Pseudomonas aeruginosa. Podocarpusflavone A shows weak activity against fungal pathogens. Podocarpusflavone A targets topoisomerase I and induces cell cycle arrest and apoptosis in MCF-7 cells. Podocarpusflavone A can be used for studies on cancer, bacterial and fungal infections. | ||||||||||||||||||||
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Sotetsuflavone | Sotetsuflavone is a flavonoid that can be isolated from Cycas revolute. Sotetsuflavone inhibits phosphorylation of PI3K, Akt, mTOR, JNK, and p38 MAPK; modulates expression of Cyclin D1, CDK4, Bcl-2, Bax, cleaved caspases 3/9, MMP-9, TGF-β, STAT3, and β-catenin. Sotetsuflavone induces G0/G1 cell cycle arrest, apoptosis, autophagy, and intracellular ROS elevation, inhibits cancer cell proliferation. Sotetsuflavone inhibits tumor growth in mouse tumor xenograft models. Sotetsuflavone can be used for the research of non-small cell lung cancer and Crohn’s disease. | |||||||||||||||||||||
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References
- [1]. Al-Sayed E, et, al. Protective role of Cupressuflavone from Cupressus macrocarpa against carbon tetrachloride-induced hepato- and nephrotoxicity in mice. Planta Med. 2014 Dec;80(18):1665-71. [Content Brief]
- [2]. Al-Sayed E, et, al. Anti-inflammatory and analgesic activities of cupressuflavone from Cupressus macrocarpa: Impact on pro-inflammatory mediators. Drug Dev Res. 2018 Feb;79(1):22-28. [Content Brief]
- [3]. Koriem KMM, et, al. Protective effect of Cupressus sempervirens extract against indomethacin-induced gastric ulcer in rats. Interdiscip Toxicol. 2015 Mar;8(1):25-34. [Content Brief]
