4008-48-4
4008-48-4
Chemical Structure
Nitroxoline
Synonym(s): 8-Hydroxy-5-nitroquinoline; 5-Nitro-8-quinolinol
- CAS No.: 4008-48-4
- Formula:C9H6N2O3
- Molecular Weight:190.16
IUPAC Name: 5-nitroquinolin-8-ol
InChIKey: RJIWZDNTCBHXAL-UHFFFAOYSA-N
SMILES: OC1=C2N=CC=CC2=C([N+]([O-])=O)C=C1
Biological Activity: Nitroxoline (8-Hydroxy-5-nitroquinoline), an antibiotic, is an orally active antibiofilm agent. Nitroxoline reduces the formation and induces the dispersal of Pseudomonas aeruginosa biofilms by chelation of iron and zinc. Nitroxoline can be used for the urinary tract infections and cancer research[1][2][3].
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Nitroxoline | 99.90% | Nitroxoline (8-Hydroxy-5-nitroquinoline), an antibiotic, is an orally active antibiofilm agent. Nitroxoline reduces the formation and induces the dispersal of Pseudomonas aeruginosa biofilms by chelation of iron and zinc. Nitroxoline can be used for the urinary tract infections and cancer research. | ||||||||||||||||||||
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Nitroxoline (Standard) | 99.64% | Nitroxoline (Standard) is the analytical standard of Nitroxoline. This product is intended for research and analytical applications. Nitroxoline (8-Hydroxy-5-nitroquinoline), an antibiotic, is an orally active antibiofilm agent. Nitroxoline reduces the formation and induces the dispersal of Pseudomonas aeruginosa biofilms by chelation of iron and zinc. Nitroxoline can be used for the urinary tract infections and cancer research. | ||||||||||||||||||||
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Nitroxoline-d4 | Nitroxoline-d4 is the deuterium labeled Nitroxoline. Nitroxoline is an antibiotic that has proven to be very effective at combating biofilm infections. Nitroxoline functions by chelating Fe2+ and Zn2+ ions from the biofilm matrix. | |||||||||||||||||||||
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References
- [1]. A Sobke, et al. The urinary antibiotic 5-nitro-8-hydroxyquinoline (Nitroxoline) reduces the formation and induces the dispersal of Pseudomonas aeruginosa biofilms by chelation of iron and zinc. Antimicrob Agents Chemother. 2012 Nov;56(11):6021-5. [Content Brief]
- [2]. Jin-Guo Yu, et al. Nitroxoline induces cell apoptosis by inducing MDM2 degradation in small-cell lung cancer. Kaohsiung J Med Sci. 2019 Apr;35(4):202-208. [Content Brief]
