4185-01-7
Chemical Structure
3-Oxo deoxycholic acid
- CAS No.: 4185-01-7
- Formula:C24H38O4
- Molecular Weight:390.56
IUPAC Name: 2-(3,4-dichlorophenyl)-2,2-difluoroethan-1-ol
InChIKey: WMUMZOAFCDOTRW-OVEHVULHSA-N
SMILES: C[C@@H]([C@H]1CC[C@]2([C@@]3(CC[C@@]4(CC(CC[C@@]4([C@]3(C[C@@H]([C@]12C)O)[H])C)=O)[H])[H])[H])CCC(O)=O
Biological Activity: 3-Oxo deoxycholic acid is a secondary bile acid and a metabolic intermediate of Deoxycholic acid (HY-N0593) under the action of gut microbiota. 3-Oxo deoxycholic acid enhances the intestinal barrier by upregulating tight junction proteins, and maintains bile acid homeostasis and reduces toxicity via the gut bacterial enzyme system. 3-Oxo deoxycholic acid can be used in research on colonic barrier dysfunction and colonic inflammation[1][2][3][4][5][6].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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3-Oxo deoxycholic acid | 99.88% | 3-Oxo deoxycholic acid is a secondary bile acid and a metabolic intermediate of Deoxycholic acid (HY-N0593) under the action of gut microbiota. 3-Oxo deoxycholic acid enhances the intestinal barrier by upregulating tight junction proteins, and maintains bile acid homeostasis and reduces toxicity via the gut bacterial enzyme system. 3-Oxo deoxycholic acid can be used in research on colonic barrier dysfunction and colonic inflammation. | ||||||||||||||||||||
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References
- [1]. Zinner SH, et al. Effect of mixing on rifampin bactericidal activity against staphylococci. Antimicrobial agents and chemotherapy. 1981 Aug;20(2):267-9.
- [2]. Posa M, et al. Hydrophobicity and haemolytic potential of oxo derivatives of cholic, deoxycholic and chenodeoxycholic acids. Steroids. 2010 Jun;75(6):424-31.
- [3]. Nadler M, et al. Following the structural changes during zinc-induced crystallization of charged membranes using time-resolved solution X-ray scattering. Soft Matter. 2011;7:1512.
- [4]. Funabashi M, et al. A metabolic pathway for bile acid dehydroxylation by the gut microbiome. Nature. 2020 Jun;582(7813):566-570.
- [5]. Ma Y, et al. Bile Acid Derivatives Effectively Prevented High-Fat Diet-Induced Colonic Barrier Dysfunction. Molecular nutrition & food research. 2023 May;67(10):e2200649.
- [6]. Mythen SM, et al. Targeted Synthesis and Characterization of a Gene Cluster Encoding NAD(P)H-Dependent 3α-, 3β-, and 12α-Hydroxysteroid Dehydrogenases from Eggerthella CAG:298, a Gut Metagenomic Sequence. Appl Environ Microbiol. 2018;84(7):e02475-17.
