4311-88-0
4311-88-0
Chemical Structure
Necrostatin-1
Synonym(s): Nec-1
- CAS No.: 4311-88-0
- Formula:C13H13N3OS
- Molecular Weight:259.33
IUPAC Name: 5-((1H-indol-3-yl)methyl)-3-methyl-2-thioxoimidazolidin-4-one
InChIKey: TXUWMXQFNYDOEZ-UHFFFAOYSA-N
SMILES: O=C(C(CC1=CNC2=C1C=CC=C2)N3)N(C)C3=S
Biological Activity: Necrostatin-1 (Nec-1) is a potent and cross the blood-brain barrier necroptosis inhibitor with an EC50 of 490 nM in Jurkat cells. Necrostatin-1 inhibits RIP1 kinase (EC50=182 nM). Necrostatin-1 is also an IDO inhibitor[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Necrostatin-1 | 99.89% | Necrostatin-1 (Nec-1) is a potent and cross the blood-brain barrier necroptosis inhibitor with an EC50 of 490 nM in Jurkat cells. Necrostatin-1 inhibits RIP1 kinase (EC50=182 nM). Necrostatin-1 is also an IDO inhibitor. | ||||||||||||||||||||
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Necrostatin-1 (Standard) | 99.19% | Necrostatin-1 (Standard) is the analytical standard of Necrostatin-1. This product is intended for research and analytical applications. Necrostatin-1 (Nec-1) is a potent and cross the blood-brain barrier necroptosis inhibitor with an EC50 of 490 nM in Jurkat cells. Necrostatin-1 inhibits RIP1 kinase (EC50=182 nM). Necrostatin-1 is also an IDO inhibitor. | ||||||||||||||||||||
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References
