444288-86-2
444288-86-2
Chemical Structure
CC-3060
- CAS No.: 444288-86-2
- Formula:C22H17N3O5
- Molecular Weight:403.39
InChIKey: GRICLJZNEMDVMA-UHFFFAOYSA-N
SMILES: O=C1NC(C(CC1)N2C(C3=C(C2=O)C(NCC4=CC5=C(C=CC=C5)O4)=CC=C3)=O)=O
Biological Activity: CC-3060 is a molecular glue modulator targeting Cereblon (CRBN) E3 ubiquitin ligase and ZBTB16 degrader with a DC50 of 0.47 nM in HT-1080 cells. CC-3060 engages structural degrons on ZBTB16’s ZnF1 or ZnF3 domains for fusion protein substrates. CC-3060 can be used for the research of acute promyelocytic leukemia[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CC-3060 | 99.7% | CC-3060 is a molecular glue modulator targeting Cereblon (CRBN) E3 ubiquitin ligase and ZBTB16 degrader with a DC50 of 0.47 nM in HT-1080 cells. CC-3060 engages structural degrons on ZBTB16’s ZnF1 or ZnF3 domains for fusion protein substrates. CC-3060 can be used for the research of acute promyelocytic leukemia. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.77
HY-144985E3 ligase Ligand 23 -
Similarity Score 0.69
HY-157215HDAC-IN-66 -
Similarity Score 0.67
HY-168964Ethanolamine-Thalidomide-4-OH -
Similarity Score 0.67
HY-W957364Pomalidomide-C2-Br -
Similarity Score 0.67
HY-128846Pomalidomide-C2-NH2 -
Similarity Score 0.66
HY-128846APomalidomide-C2-NH2 hydrochloride -
Similarity Score 0.66
HY-W410002Pomalidomide-propargyl -
Similarity Score 0.66
HY-131717Thalidomide-NH-CH2-COOH -
Similarity Score 0.66
HY-177768HDAC-IN-96 -
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