4630-07-3
4630-07-3
Chemical Structure
Valencene
- CAS No.: 4630-07-3
- Formula:C15H24
- Molecular Weight:204.35
IUPAC Name: (3R,4aS,5R)-4a,5-dimethyl-3-(prop-1-en-2-yl)-1,2,3,4,4a,5,6,7-octahydronaphthalene
InChIKey: QEBNYNLSCGVZOH-NFAWXSAZSA-N
SMILES: C=C([C@@H]1CCC2=CCC[C@@H](C)[C@]2(C)C1)C
Biological Activity: Valencene is a sesquiterpene that can be isolated from Cyperus rotundus. Valencene possesses antiallergic, antimelanogenesis, anti-infammatory, and antioxidant activitivies. Valencene inhibits the exaggerated expression of Th2 chemokines and proinflammatory chemokines through blockade of the NF-κB pathway. Valencene inhibits the production and expression of proinflammatory cytokines IL-1β and IL-6 in LPS-stimulated RAW 264.7 cells. Valencene can reduce atopic dermatitis symptoms and recover decreased expression of filaggrin in DNCB-sensitized mouse model[1][2][3].
| Cat. No. | Nom du produit | Pureté | Description | Pricing | |||||||||||||||||||
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Valencene | 80.24% | Valencene is a sesquiterpene that can be isolated from Cyperus rotundus. Valencene possesses antiallergic, antimelanogenesis, anti-infammatory, and antioxidant activitivies. Valencene inhibits the exaggerated expression of Th2 chemokines and proinflammatory chemokines through blockade of the NF-κB pathway. Valencene inhibits the production and expression of proinflammatory cytokines IL-1β and IL-6 in LPS-stimulated RAW 264.7 cells. Valencene can reduce atopic dermatitis symptoms and recover decreased expression of filaggrin in DNCB-sensitized mouse model. | ||||||||||||||||||||
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Valencene (Standard) | ≥98% | Valencene (Standard) is the analytical standard of Valencene. This product is intended for research and analytical applications. Valencene is a sesquiterpene that can be isolated from Cyperus rotundus. Valencene possesses antiallergic, antimelanogenesis, anti-infammatory, and antioxidant activitivies. Valencene inhibits the exaggerated expression of Th2 chemokines and proinflammatory chemokines through blockade of the NF-κB pathway. Valencene inhibits the production and expression of proinflammatory cytokines IL-1β and IL-6 in LPS-stimulated RAW 264.7 cells. Valencene can reduce atopic dermatitis symptoms and recover decreased expression of filaggrin in DNCB-sensitized mouse model. | ||||||||||||||||||||
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Calarene | Calarene is an insecticide that can be obtained from the stem of Kadsura heteroclite. Calarene is toxic to Meloidogyne incognita, Sitophilus zeamais, and mosquitoes. Calarene can be used in the research of plant pests and mosquito control. | |||||||||||||||||||||
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α-Selinene | α-Selinene is a natural product that can be extracted from Psidium guajava L.. α-Selinene is a sesquiterpene compound with volatility. | |||||||||||||||||||||
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α-Bulnesene | α-Bulnesene is a novel PAF receptor antagonist with the IC50 of 17.62 μM. α-Bulnesene can be isolated from Pogostemon cablin. α-Bulnesene shows inhibitory effect on platelet-activating factor and arachidonic acid induced rabbit platelet aggregation. | |||||||||||||||||||||
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β-Caryophyllene (Standard) | 98.78% | β-Caryophyllene (Standard) is the analytical standard of β-Caryophyllene. This product is intended for research and analytical applications. β-Caryophyllene is a CB2 receptor agonist. | ||||||||||||||||||||
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(+)-trans-Isolimonene | (+)-trans-Isolimonene is a natural monoterpene isolated from essential oil. | |||||||||||||||||||||
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Amorphadiene | Amorphadiene is the precursor to the antimalarial agent artemisinin, which is produced through the amorphadiene synthase (ADS)-catalyzed cyclization of farnesyl pyrophosphate (FPP) yeast. | |||||||||||||||||||||
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α-Guaiene | 95.07% | α-Guaiene is a natural sesquiterpene and fungicidal agent found in Pogostemon cablin (patchouli) essential oil. α-Guaiene suppresses the growth of Aspergillus niger, Candida albicans, Microsporum gypseum, and Trichophyton mentagrophytes. α-Guaiene can be used for the study of fungal infection. | ||||||||||||||||||||
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β-Selinene | β-Selinene is a sesquiterpene hydrocarbon essential oil component. β-Selinene is the main component of the essential oil from the aerial parts of Salvia amarissima, and is present in the leaf essential oil of Croton floribundus and the seed extract of Cleistocalyx nervosum var. paniala. | |||||||||||||||||||||
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(-)-Limonene | 98.59% | (-)-Limonene ((S)-(-)-Limonene) is orally active and can cause mild bronchoconstriction. (-)-Limonene alleviates cytosolic and mitochondrial oxidative stress by inhibiting the increase of calcium ions (Ca2+) and Ca2+/calmodulin-dependent protein kinase II (CaMKII). It also exerts anti-stress effects by inhibiting the activity of the hypothalamic-pituitary-adrenal (HPA) axis. Additionally, (-)-Limonene can be used as an antibacterial agent in aquaculture. | ||||||||||||||||||||
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References
- [1]. Yang IJ, et al. Inhibitory Effect of Valencene on the Development of Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice. Evid Based Complement Alternat Med. 2016;2016:9370893. [Content Brief]
- [2]. Frohwitter J, et al. Production of the sesquiterpene (+)-valencene by metabolically engineered Corynebacterium glutamicum. J Biotechnol. 2014 Dec 10;191:205-13. [Content Brief]
- [3]. Marques FM, et al. In vitro anti-inflammatory activity of terpenes via suppression of superoxide and nitric oxide generation and the NF-κB signalling pathway. Inflammopharmacology. 2019 Apr;27(2):281-289. [Content Brief]
