477-27-0
477-27-0
Chemical Structure
Colchiceine
Synonym(s): O10-Demethylcolchicine
- CAS No.: 477-27-0
- Formula:C21H23NO6
- Molecular Weight:385.41
IUPAC Name: (S)-N-(10-hydroxy-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide
InChIKey: PRGILOMAMBLWNG-HNNXBMFYSA-N
SMILES: CC(N[C@H](C1=C2)CCC3=CC(OC)=C(OC)C(OC)=C3C1=CC=C(O)C2=O)=O
Biological Activity: Colchiceine is one of several metabolites of the anti-gout medication Colchicine (HY-16569). Colchicine is a tubulin inhibitor and a microtubule disrupting agent, and may protect rats from developing liver injury and fibrosis[1][2][3].
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Colchiceine | Colchiceine is one of several metabolites of the anti-gout medication Colchicine (HY-16569). Colchicine is a tubulin inhibitor and a microtubule disrupting agent, and may protect rats from developing liver injury and fibrosis. | |||||||||||||||||||||
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Colchiceine (Standard) | ≥98% | Colchiceine (Standard) is the analytical standard of Colchiceine. This product is intended for research and analytical applications. Colchiceine is one of several metabolites of the anti-gout medication Colchicine (HY-16569). Colchicine is a tubulin inhibitor and a microtubule disrupting agent, and may protect rats from developing liver injury and fibrosis. | ||||||||||||||||||||
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Colchiceine-d3 | Colchiceine-d3 is the deuterium labeled Colchiceine. | |||||||||||||||||||||
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References
- [1]. Rodríguez L, et al. Effects of colchicine and colchiceine in a biochemical model of liver injury and fibrosis. Arch Med Res. 1998;29(2):109-116. [Content Brief]
- [2]. Nava-Ocampo AA, et al. Effect of colchiceine and ursodeoxycholic acid on hepatocyte and erythrocyte membranes and liver histology in experimentally induced carbon tetrachloride cirrhosis in rats. Eur J Clin Invest. 1997;27(1):77-84. [Content Brief]
- [3]. Edström A, et al. Inhibition of fast axonal transport and microtubule polymerization in vitro by colchicine and colchiceine. Acta Physiol Scand. 1979;107(3):233-237. [Content Brief]
