491-64-5
Chemical Structure
Isogentisin
- CAS No.: 491-64-5
- Formula:C14H10O5
- Molecular Weight:258.23
IUPAC Name: 1,3-dihydroxy-7-methoxy-9H-xanthen-9-one
InChIKey: FVIYCYAHKMJVJK-UHFFFAOYSA-N
SMILES: O=C1C2=C(C=C(C=C2O)O)OC3=C1C=C(C=C3)OC
Biological Activity: Isogentisin is a Monoamine oxidase inhibitor. Isogentisin reduces basal Caspase-3 activity levels. Isogentisin induces mild intracellular oxidative stress, reduces protein oxidation after prolonged incubation, and does not significantly reduce ROS generated by CSE or H2O2. Isogentisin protects cells from cigarette smoke extract-, hydrogen peroxide-, and UV-induced death through cellular interactions rather than chemical neutralization of smoke. Isogentisin can be used in research on endothelial injury[1][2][3].
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Isogentisin | 99.18% | Isogentisin is a Monoamine oxidase inhibitor. Isogentisin reduces basal Caspase-3 activity levels. Isogentisin induces mild intracellular oxidative stress, reduces protein oxidation after prolonged incubation, and does not significantly reduce ROS generated by CSE or H2O2. Isogentisin protects cells from cigarette smoke extract-, hydrogen peroxide-, and UV-induced death through cellular interactions rather than chemical neutralization of smoke. Isogentisin can be used in research on endothelial injury. | ||||||||||||||||||||
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Similarity Score 0.90
HY-N4279Gentisin -
Similarity Score 0.86
HY-118166RGentisein (Standard) -
Similarity Score 0.83
HY-172944GPR40 Activator 3 -
Similarity Score 0.81
HY-N101571,3,7-Trihydroxy-2-methoxyxanthone -
Similarity Score 0.80
HY-N3295Mesuaxanthone A -
Similarity Score 0.80
HY-N1994Swertianine -
Similarity Score 0.79
HY-N10836Montixanthone -
Similarity Score 0.79
HY-N127861,3-Dihydroxy-2-methoxyxanthone -
Similarity Score 0.79
HY-N15656Swertinin -
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References
- [1]. Osamu S, et al. Inhibition of monoamine oxidase by isogentisin and its 3-0-glucoside. Biochemical Pharmacology. 1978 Jan 1;27(16):2075-8.
- [2]. Schmieder A, et al. Isogentisin--a novel compound for the prevention of smoking-caused endothelial injury. Atherosclerosis. 2007 Oct;194(2):317-25. [Content Brief]
- [3]. Buchwald W, et al. Gentianae radix. InThe Gentianaceae-Volume 2: Biotechnology and Applications 2015 Jun 18 (pp. 403-419). Berlin, Heidelberg: Springer Berlin Heidelberg.
