500-92-5
500-92-5
Chemical Structure
Proguanil
- CAS No.: 500-92-5
- Formula:C11H16ClN5
- Molecular Weight:253.73
InChIKey: SSOLNOMRVKKSON-UHFFFAOYSA-N
SMILES: N=C(NC1=CC=C(Cl)C=C1)NC(NC(C)C)=N
Biological Activity: Proguanil, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil is a dihydrofolate reductase (DHFR) inhibitor[1][2].
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Proguanil | 99.84% | Proguanil, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil is a dihydrofolate reductase (DHFR) inhibitor. | ||||||||||||||||||||
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Proguanil (Standard) | ≥98% | Proguanil (Standard) is the analytical standard of Proguanil. This product is intended for research and analytical applications. Proguanil, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil is a dihydrofolate reductase (DHFR) inhibitor. | ||||||||||||||||||||
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Proguanil-d4 | Proguanil-d4 is the deuterium labeled Proguanil. Proguanil, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil is a dihydrofolate reductase (DHFR) inhibitor. | |||||||||||||||||||||
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Proguanil-d6 | Proguanil-d6 is the deuterium labeled Proguanil, which is a prophylactic antimalarial agent. | |||||||||||||||||||||
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References
- [1]. Pudney M, et al. Atovaquone and proguanil hydrochloride: a review of nonclinical studies. J Travel Med. 1999 May;6 Suppl 1:S8-12. [Content Brief]
- [2]. Srivastava IK, et al. A mechanism for the synergistic antimalarial action of atovaquone and proguanil. Antimicrob Agents Chemother. 1999 Jun;43(6):1334-9. [Content Brief]
