53-96-3
53-96-3
Chemical Structure
2-Acetamidofluorene
- CAS No.: 53-96-3
- Formula:C15H13NO
- Molecular Weight:223.28
IUPAC Name: N-(9H-fluoren-2-yl)acetamide
InChIKey: CZIHNRWJTSTCEX-UHFFFAOYSA-N
SMILES: CC(NC1=CC2=C(C=C1)C(C=CC=C3)=C3C2)=O
Biological Activity: 2-Acetamidofluorene is a potent carcinogenan. 2-Acetamidofluorene is can be used fot induction of hepatocellular carcinoma (HCC) and multiple primary tumours[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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2-Acetamidofluorene | 99.50% | 2-Acetamidofluorene is a potent carcinogenan. 2-Acetamidofluorene is can be used fot induction of hepatocellular carcinoma (HCC) and multiple primary tumours. | ||||||||||||||||||||
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2-Acetamidofluorene (Standard) | ≥98% | 2-Acetamidofluorene is a potent carcinogenan. 2-Acetamidofluorene is can be used fot induction of hepatocellular carcinoma (HCC) and multiple primary tumours. | ||||||||||||||||||||
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NSC-80141 | NSC-80141 is a Kinesin-5 inhibitor. NSC-80141 exerts selective inhibitory activity against human kinesin-5 (HsEg5) (IC50: 9.4 μM), while shows weak inhibitory activity against Plasmodium kinesin-5 (PvEg5) (IC50: 27.3 μM). NSC-80141 serves as a tool compound for distinguishing human and Plasmodium homologous proteins. | |||||||||||||||||||||
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Cicloprofen | Cicloprofen is an anti-inflammatory agent | |||||||||||||||||||||
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L-Alanine-2-naphthylamide | 99.68% | L-Alanine-2-naphthylamide (Alanine β-naphthylamide) is an Aminopeptidase (E.C. 3.4.11.) substrate and detection reagent. L-Alanine-2-naphthylamide detects the functional activity of aminopeptidase in the intestine of larval whitefish (Coregonus lavaretus). L-Alanine-2-naphthylamide serves as an initiator in the N-carboxyanhydride (NCA) method for synthesizing poly (β-benzyl-L-aspartate) polymers with a terminal 2-naphthyl energy donor group. | ||||||||||||||||||||
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K 01-162 | 98.0% | K 01-162 (K162) inhibits the fibril formation of Aβ peptides and eliminates their neurotoxicity. K 01-162 binds with Aβ42 peptide with an EC50 value of 80 nM. K 01-162 binds directly to AβO with a KD value of 19 μM. K 01-162 is capable of penetrating the brain and can be used for the research of Alzheimer’s disease. | ||||||||||||||||||||
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SF1670 | 98.57% | SF1670 is a potent and specific phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor. | ||||||||||||||||||||
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ALR2-IN-7 | 99.94% | ALR2-IN-7 (Compound 5a) is a highly potent and selective aldose reductase (ALR2/AKR1B1) inhibitor (Ki=8.71 nM). ALR2-IN-7 is promising for research of diabetic complications (e.g., retinopathy, nephropathy) and cancers. | ||||||||||||||||||||
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SARS-CoV-2-IN-115 | SARS-CoV-2-IN-115 (Compound 3e) is a SARS-CoV-2 inhibitor. SARS-CoV-2-IN-115 has potent antiviral activity against SARS-CoV-2 in infected Calu-3 cells (EC50: 1.7 μM). SARS-CoV-2-IN-115 effectively inhibits the activity of human dihydroorotate dehydrogenase (HsDHODH) (IC50: 1.5 μM). SARS-CoV-2-IN-115 preserves immune response without antiproliferative effects on CD4 T cells . | |||||||||||||||||||||
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1-([1,1'-Biphenyl]-4-yl)urea | 1-(-4-yl) urea (compound 44) is a biphenyl urea analog . | |||||||||||||||||||||
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9H-Fluorene-2,7-dicarboxylic acid | 98.23% | 9H-Fluorene-2,7-dicarboxylic acid is a metal-organic framework (MOF). | ||||||||||||||||||||
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Azapetine hydrochloride | Azapetine hydrochloride is an antagonist of α1-adrenoceptor, with an IC50 of 0.205 μM at rat α1-adrenoceptor and an IC50 of 1.3 μM at rat α2-adrenoceptor, and exhibits higher selectivity for α1-adrenoceptor than for α2-adrenoceptor. Azapetine hydrochloride functionally blocks postsynaptic α1-adrenoceptors, and at higher concentrations, it blocks presynaptic α2-adrenoceptors, central α-adrenoceptors, and H2 histamine receptors. Azapetine hydrochloride is used in related research on hypotension. | |||||||||||||||||||||
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References
- [1]. Tan B, et al. Anti-hepatoma effect of arsenic trioxide on experimental liver cancer induced by 2-acetamidofluorene in rats. World J Gastroenterol. 2005 Oct 14;11(38):5938-43. [Content Brief]
- [2]. CAMPBELL JG. Induction of multiple primary tumours in fowls with 2-acetamidofluorene. Br J Cancer. 1955 Mar;9(1):163-9. [Content Brief]
