531-46-4
Chemical Structure
Fluoflavine
Synonym(s): ML-090
- CAS No.: 531-46-4
- Formula:C14H10N4
- Molecular Weight:234.26
IUPAC Name: 5,11-dihydroquinoxalino[2,3-b]quinoxaline
InChIKey: WGKYYZDYHYOKQV-UHFFFAOYSA-N
SMILES: C1(N2)=NC3=C(C=CC=C3)NC1=NC4=C2C=CC=C4
Biological Activity: Fluoflavine (ML-090) is a selective NOX1 inhibitor and reactive oxygen species inhibitor. Fluoflavine reduces reactive oxygen species production, NOX1-mediated downstream signaling events, and oxygen-glucose deprivation-induced retinal ganglion cell death. Fluoflavine inhibits NADPH oxidase activity and pathological retinal neovascularization induced by oxygen-induced retinopathy in the retinas of ischemic mice. Fluoflavine can be used in studies related to retinal ischemia-reperfusion injury and proliferative retinopathy[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Fluoflavine | 98.47% | Fluoflavine (ML-090) is a selective NOX1 inhibitor and reactive oxygen species inhibitor. Fluoflavine reduces reactive oxygen species production, NOX1-mediated downstream signaling events, and oxygen-glucose deprivation-induced retinal ganglion cell death. Fluoflavine inhibits NADPH oxidase activity and pathological retinal neovascularization induced by oxygen-induced retinopathy in the retinas of ischemic mice. Fluoflavine can be used in studies related to retinal ischemia-reperfusion injury and proliferative retinopathy. | ||||||||||||||||||||
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References
- [1]. Dvoriantchikova G, et al. Neuronal NAD(P)H oxidases contribute to ROS production and mediate RGC death after ischemia. Invest Ophthalmol Vis Sci. 2012;53(6):2823-2830. Published 2012 May 14. [Content Brief]
- [2]. Kaur G, et al. NADPH oxidase 1-PKCδ-dependent ZO-1 phosphorylation mediates IL-33-induced inner blood-retinal barrier disruption in proliferative retinopathies. Am J Physiol Cell Physiol. 2025;329(5):C1577-C1592. [Content Brief]
