532-94-5
Chemical Structure
Sodium hippurate, 98%
Synonym(s): N-Benzoylglycine sodium, 98%
- CAS No.: 532-94-5
- Formula:C9H8NNaO3
- Molecular Weight:201.16
IUPAC Name: sodium benzoylglycinate
InChIKey: ZBCAZEFVTIBZJS-UHFFFAOYSA-M
SMILES: O=C(CNC(C1=CC=CC=C1)=O)O[Na]
Biological Activity: Sodium hippurate, 98% is an orally active metabolite. Sodium hippurate, 98% can be produced by intestinal microorganisms from the metabolism of polyphenols, benzoic acid. Sodium hippurate, 98% decreases NRF2, MMP9 and leads to ROS accumulation. Sodium hippurate, 98% activates TGFβ/SMAD signaling. Sodium hippurate, 98% improves hyperuricemia and colitis. Sodium hippurate, 98% can also be used in cardiovascular disease research[1][2][3][4]. [5][6][7][8][9].
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Sodium hippurate, 98% | 99.91% | Sodium hippurate, 98% is an orally active metabolite. Sodium hippurate, 98% can be produced by intestinal microorganisms from the metabolism of polyphenols, benzoic acid. Sodium hippurate, 98% decreases NRF2, MMP9 and leads to ROS accumulation. Sodium hippurate, 98% activates TGFβ/SMAD signaling. Sodium hippurate, 98% improves hyperuricemia and colitis. Sodium hippurate, 98% can also be used in cardiovascular disease research. . | ||||||||||||||||||||
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- [1]. Bergmeyer H U, et al. Biochemical reagents[M]//Methods of Enzymatic Analysis. Academic Press, 1965: 967-1037.
- [2]. Edwards SJ, et al. (-)-Epicatechin and its colonic metabolite hippuric acid protect against dexamethasone-induced atrophy in skeletal muscle cells. J Nutr Biochem. 2022 Dec;110:109150. [Content Brief]
- [3]. Santhakumar AB, et al. The ex vivo antiplatelet activation potential of fruit phenolic metabolite hippuric acid. Food Funct. 2015 Aug;6(8):2679-83. [Content Brief]
- [4]. Sun B, et al. Hippuric Acid Promotes Renal Fibrosis by Disrupting Redox Homeostasis via Facilitation of NRF2-KEAP1-CUL3 Interactions in Chronic Kidney Disease. Antioxidants (Basel). 2020 Aug 25;9(9):783. [Content Brief]
- [5]. Xu YX, et al. Alistipes indistinctus-derived hippuric acid promotes intestinal urate excretion to alleviate hyperuricemia. Cell Host Microbe. 2024 Mar 13;32(3):366-381.e9. [Content Brief]
- [6]. Yang Y, et al. Hippuric acid alleviates dextran sulfate sodium-induced colitis via suppressing inflammatory activity and modulating gut microbiota. Biochem Biophys Res Commun. 2024 May 28;710:149879. [Content Brief]
- [7]. Zhao H, et al. Hippuric acid and 3-(3-hydroxyphenyl) propionic acid inhibit murine osteoclastogenesis through RANKL-RANK independent pathway. J Cell Physiol. 2020 Jan;235(1):599-610. [Content Brief]
- [8]. Griffith W H. Inhibition of tissue respiration by sodium benzoate and sodium hippurate. Proceedings of the Society for Experimental Biology and Medicine, 1937, 37(2): 279-280.
- [9]. Chen JR, et al. GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice. Commun Biol. 2021 Jan 8;4(1):53. [Content Brief]
Keywords
