54-25-1
54-25-1
Chemical Structure
6-Azuridine
Synonym(s): 6-Azauridine
- CAS No.: 54-25-1
- Formula:C8H11N3O6
- Molecular Weight:245.19
IUPAC Name: 2-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,2,4-triazine-3,5(2H,4H)-dione
InChIKey: WYXSYVWAUAUWLD-SHUUEZRQSA-N
SMILES: O=C(N1)N([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)N=CC1=O
Biological Activity: 6-Azuridine (6-Azauridine) is an orally active purine nucleoside analogue. 6-Azuridine activates autophagic flux, induces Apoptosis that depends on AMPK and p53. 6-Azuridine exhibit both antitumor and antiviral activities[1][2][3][4][5][6].
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6-Azuridine | 99.83% | 6-Azuridine (6-Azauridine) is an orally active purine nucleoside analogue. 6-Azuridine activates autophagic flux, induces Apoptosis that depends on AMPK and p53. 6-Azuridine exhibit both antitumor and antiviral activities. | ||||||||||||||||||||
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6-Azuridine (Standard) | ≥98% | 6-Azuridine (Standard) is the analytical standard of 6-Azuridine. This product is intended for research and analytical applications. 6-Azuridine (6-Azauridine) is an orally active purine nucleoside analogue. 6-Azuridine activates autophagic flux, induces Apoptosis that depends on AMPK and p53. 6-Azuridine exhibit both antitumor and antiviral activities. | ||||||||||||||||||||
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References
- [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. [Content Brief]
- [2]. Yallappa G N, et al. Design and synthesis of pyrazole derivatives for in vitro screening to protect angiotensin-converting enzyme 2 human cells against COVID-19. Current Medicine Research and Practice, 2021, 11(5): 206-210.
- [3]. Janeway CM, et al. Effects of 6-azauridine on nucleotides, orotic acid, and orotidine in L5178Y mouse lymphoma cells in vitro. Cancer Res. 1977 Dec;37(12):4382-8. [Content Brief]
- [4]. Cha YE, et al. 6-Azauridine Induces Autophagy-Mediated Cell Death via a p53- and AMPK-Dependent Pathway. Int J Mol Sci. 2021 Mar 14;22(6):2947. [Content Brief]
- [5]. Steffenhagen KA, et al. Evaluation of 6-azauridine and 5-iododeoxyuridine in the treatment of experimental viral infections. J Infect Dis. 1976 Jun;133(6):603-12. [Content Brief]
- [6]. Conn HO, et al. Effect of 6-azauridine on plasma cell tumors of mice: correlation of antitumor effect with inhibition of orotic acid metabolism. Cancer Res. 1967 Apr;27(4):618-25. [Content Brief]
