54260-72-9
Chemical Structure
13-Methylberberine chloride
Synonym(s): 13-Methylberberinium chloride
- CAS No.: 54260-72-9
- Formula:C21H20ClNO4
- Molecular Weight:385.84
IUPAC Name: 9,10-dimethoxy-13-methyl-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium chloride
InChIKey: MLEFNGNLISNJEQ-UHFFFAOYSA-M
SMILES: CC1=C(C=CC(OC)=C2OC)C2=C[N+]3=C1C4=CC(OCO5)=C5C=C4CC3.[Cl-]
Biological Activity: 13-Methylberberine chloride (13-Methylberberinium chloride), a berberine analogue, has anti-adipogenic and antitumor activities. 13-Methylberberine chloride (13-Methylberberinium chloride) increases production of IL-12 and inhibits the expression of iNOS at posttranscriptional level in macrophages activated with LPS[1][2][3].
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13-Methylberberine chloride | 99.16% | 13-Methylberberine chloride (13-Methylberberinium chloride), a berberine analogue, has anti-adipogenic and antitumor activities. 13-Methylberberine chloride (13-Methylberberinium chloride) increases production of IL-12 and inhibits the expression of iNOS at posttranscriptional level in macrophages activated with LPS. | ||||||||||||||||||||
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- [1]. Chow YL, et al. 13-Methylberberine, a berberine analogue with stronger anti-adipogenic effects on mouse 3T3-L1 cells. Sci Rep. 2016 Dec 5;6:38129. [Content Brief]
- [2]. Iwasa K, et al. In vitro cytotoxicity of the protoberberine-type alkaloids. J Nat Prod. 2001 Jul;64(7):896-8. [Content Brief]
- [3]. Lee DU, et al. Effects of 13-alkyl-substituted berberine alkaloids on the expression of COX-II, TNF-alpha, iNOS, and IL-12 production in LPS-stimulated macrophages. Life Sci. 2003 Aug 1;73(11):1401-12. [Content Brief]
Keywords
