545-46-0
545-46-0
Chemical Structure
Uvaol
- CAS No.: 545-46-0
- Formula:C30H50O2
- Molecular Weight:442.72
IUPAC Name: (3S,4aR,6aR,6bS,8aS,11R,12S,12aS,14aR,14bR)-8a-(hydroxymethyl)-4,4,6a,6b,11,12,14b-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-ol
InChIKey: XUARCIYIVXVTAE-ZAPOICBTSA-N
SMILES: CC1(C)[C@@H](O)CC[C@]2(C)[C@@]3([H])CC=C4[C@]5([H])[C@@H](C)[C@H](C)CC[C@@](CO)5CC[C@](C)4[C@@](C)3CC[C@@]12[H]
Biological Activity: Uvaol, a triterpene present in olives and virgin olive oil, possesses anti-inflammatory properties and antioxidant effects. Uvaol is an orally active inducer of apoptosis in astroglioma cells. Uvaol also has anti-cancer activities. Uvaol attenuates pleuritis and eosinophilic inflammation in ovalbumin-induced allergy in mice[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Uvaol | 99.20% | Uvaol, a triterpene present in olives and virgin olive oil, possesses anti-inflammatory properties and antioxidant effects. Uvaol is an orally active inducer of apoptosis in astroglioma cells. Uvaol also has anti-cancer activities. Uvaol attenuates pleuritis and eosinophilic inflammation in ovalbumin-induced allergy in mice. | ||||||||||||||||||||
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Waltonitone | 99.91% | Waltonitone is a ursane-type pentacyclic triterpene isolated from Gentian waltonii Burkill. Waltonitone significantly inhibits hepatocellular carcinoma cells growth and induces apoptosis in vitro and in vivo. | ||||||||||||||||||||
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Ursolic acid | 99.02% | Ursolic acid (Prunol) is a natural pentacyclic triterpenoid carboxylic acid, exerts anti-tumor effects and is an effective compound for cancer prevention and therapy. | ||||||||||||||||||||
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Obtusalin | Obtusalin is a triterpenoid found in R. dauricum for the first time and shows UV absorption at 210 nm. Obtusalin has some antibacterial activity. | |||||||||||||||||||||
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Rubifolic acid | Rubifolic acid is a Triterpenoids product that can be isolated from the herbs of Galium verum. | |||||||||||||||||||||
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23-Hydroxyursolic acid | 23-Hydroxyursolic acid is a triterpenoid compound that can be isolated from guava (Psidium guajava) leaves. Guava-related extracts possess antibacterial, anti-diabetic, and anti-inflammatory activities, but the specific functions of 23-Hydroxyursolic acid require targeted experimental verification. | |||||||||||||||||||||
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Erythrodiol | 99.75% | Erythrodiol is an olive oil component. Erythrodiol promotes Cholesterol efflux (ChE) by selectively inhibiting the degradation of ABCA1 protein. Erythrodiol is a good candidate to be further explored for therapeutic or preventive application in the context of atherosclerosis. | ||||||||||||||||||||
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Dulcioic acid | Dulcioic acid (compound 19) is a product isolated from Tripterygium wilfordii Hook f. Dulcioic acid shows a significant inhibitory effect on cytokine production. | |||||||||||||||||||||
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3-Epiursolic Acid (Standard) | ≥98% | 3-Epiursolic Acid (Standard) is the analytical standard of 3-Epiursolic Acid (HY-N4289). This product is intended for research and analytical applications. 3-Epiursolic Acid is a natural triterpenoid and a competitive inhibitor of Cathepsin L, with an IC50 of 6.5 μM and a Ki of 19.5 μM. 3-Epiursolic Acid acts through competitive inhibition of Cathepsin L. 3-Epiursolic Acid can be used in research on Cathepsin L inhibitors and tumor-associated proteases. | ||||||||||||||||||||
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α-Amyrin | 99.99% | α-Amyrin is a pentacyclic triterpenoid compound with oral activity. α-Amyrin activates the ERK and GSK-3β signaling pathways. α-Amyrin can inhibit cancer cells proliferation and induce apoptosis. α-Amyrin shows anti-bacterial and anti-inflammation activity. α-Amyrin can reduce blood glucose level. α-Amyrin can be used for the researches of cancer, infection, inflammation, metabolic disease and neurological disease, such as breast cancer, Streptococcus oralis infection, skin inflammation and diabetes. | ||||||||||||||||||||
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Ursolic aldehyde | Ursolic aldehyde is a triterpenoid isolated from plants. | |||||||||||||||||||||
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References
- [1]. Agra LC, et al. Uvaol attenuates pleuritis and eosinophilic inflammation in ovalbumin-induced allergy in mice. Eur J Pharmacol. 2016 Jun 5;780:232-42. [Content Brief]
- [2]. Martín R, et al. Natural triterpenic diols promote apoptosis in astrocytoma cells through ROS-mediated mitochondrial depolarization and JNK activation. PLoS One. 2009 Jun 22;4(6):e5975. [Content Brief]
