1. Apoptosis
  2. Apoptosis
  3. Waltonitone

Waltonitone 

Cat. No.: HY-128366
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Waltonitone is a ursane-type pentacyclic triterpene isolated from Gentian waltonii Burkill. Waltonitone significantly inhibits hepatocellular carcinoma cells growth and induces apoptosis in vitro and in vivo.

For research use only. We do not sell to patients.

Waltonitone Chemical Structure

Waltonitone Chemical Structure

CAS No. : 1252676-55-3

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Description

Waltonitone is a ursane-type pentacyclic triterpene isolated from Gentian waltonii Burkill. Waltonitone significantly inhibits hepatocellular carcinoma cells growth and induces apoptosis in vitro and in vivo[1].

In Vitro

waltonitone (10 μM, 25 μM; for 48 hours) results in an increment of sub-G1 population in BEL-7402 cells[1].
Waltonitone (25 μM; for 48 hours) induces BEL-7402 cells apoptosis[1].
Waltonitone (25 μM; for 48 hours) can effectively activate caspase-3 in BEL-7402 cells[1].

In Vivo

Waltonitone (i.v.; 20 mg/kg or 50 mg/kg; once every two days for 16 days) inhibits BEL-7402 tumor growth in male athymic mice (BALB/c nu/nu) in vivo[1].

Molecular Weight

440.70

Formula

C₃₀H₄₈O₂

CAS No.

1252676-55-3

SMILES
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

WaltonitoneApoptosisursane-typepentacyclictriterpeneGentianwaltoniiBurkillhepatocellularcarcinomaInhibitorinhibitorinhibit

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