56-06-4
56-06-4
Chemical Structure
2,4-Diamino-6-hydroxypyrimidine
- CAS No.: 56-06-4
- Formula:C4H6N4O
- Molecular Weight:126.12
IUPAC Name: 2,6-diaminopyrimidin-4(1H)-one
InChIKey: SWELIMKTDYHAOY-UHFFFAOYSA-N
SMILES: O=C1N=C(N)NC(N)=C1
Biological Activity: 2,4-Diamino-6-hydroxypyrimidine is a specific GTP cyclohydrolase I inhibitor (the rate-limiting enzyme in de novo pterin synthesis). 2,4-Diamino-6-hydroxypyrimidine blocks Tetrahydrobiopterin (BH4) synthesis and suppresses NO production[1][2].
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2,4-Diamino-6-hydroxypyrimidine | 99.82% | 2,4-Diamino-6-hydroxypyrimidine is a specific GTP cyclohydrolase I inhibitor (the rate-limiting enzyme in de novo pterin synthesis). 2,4-Diamino-6-hydroxypyrimidine blocks Tetrahydrobiopterin (BH4) synthesis and suppresses NO production. | ||||||||||||||||||||
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2,4-Diamino-6-hydroxypyrimidine (Standard) | ≥98% | 2,4-Diamino-6-hydroxypyrimidine (Standard) is the analytical standard of 2,4-Diamino-6-hydroxypyrimidine. This product is intended for research and analytical applications. 2,4-Diamino-6-hydroxypyrimidine is a specific GTP cyclohydrolase I inhibitor (the rate-limiting enzyme in de novo pterin synthesis). 2,4-Diamino-6-hydroxypyrimidine blocks Tetrahydrobiopterin (BH4) synthesis and suppresses NO production. | ||||||||||||||||||||
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References
- [1]. Sung YJ, et al. 2,4-Diamino-6-hydroxypyrimidine, an inhibitor of GTP cyclohydrolase I, suppresses nitric oxide production by chicken macrophages. Int J Immunopharmacol. 1994 Feb;16(2):101-8. [Content Brief]
- [2]. Kazuhisa Ikemoto, et al. 2,4-Diamino-6-hydroxypyrimidine (DAHP) suppresses cytokine-induced VCAM-1 expression on the cell surface of human umbilical vein endothelial cells in a BH(4)-independent manner. Biochim Biophys Acta. Jul-Aug 2008;1780(7-8):960-5. [Content Brief]
