57-41-0
57-41-0
Chemical Structure
Phenytoin
Synonym(s): 5,5-Diphenylhydantoin
- CAS No.: 57-41-0
- Formula:C15H12N2O2
- Molecular Weight:252.27
IUPAC Name: 5,5-diphenylimidazolidine-2,4-dione
InChIKey: CXOFVDLJLONNDW-UHFFFAOYSA-N
SMILES: O=C1NC(C(C2=CC=CC=C2)(C3=CC=CC=C3)N1)=O
Biological Activity: Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Phenytoin | 99.95% | Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice. | ||||||||||||||||||||
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Phenytoin (Standard) | 99.94% | Phenytoin (Standard) is the analytical standard of Phenytoin. This product is intended for research and analytical applications. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice. | ||||||||||||||||||||
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Phenytoin-d5 | Phenytoin-d5 (5,5-Diphenylhydantoin-d5) is deuterium labeled Phenytoin. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice. | |||||||||||||||||||||
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Phenytoin-d10 | 99.50% | Phenytoin-d10 is the deuterium labeled Phenytoin. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice. | ||||||||||||||||||||
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Phenytoin-15N2,13C | 99.84% | Phenytoin-15N2,13C is the 13C and 15N labeled Phenytoin. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice. | ||||||||||||||||||||
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5,5-Diphenylbarbituric acid | 5,5-Diphenylbarbituric acid is an organic compound belonging to the derivatives of barbituric acid. 5,5-Diphenylbarbituric acid can be used for seizure study. | |||||||||||||||||||||
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5-(4-Hydroxyphenyl)-5-phenyl hydantoin-15N2,d5 | 5-(4-Hydroxyphenyl)-5-phenyl hydantoin-15N2,d5 is the deuterium and 15N labeled 5-(4-Hydroxyphenyl)-5-phenyl hydantoin. | |||||||||||||||||||||
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(±)-N-3-Benzylnirvanol | 99.86% | (±)-N-3-Benzylnirvanol is a racemic mixture of (+)-N-3-Benzylnirvanol and (-)-N-3-Benzylnirvanol. (+)-N-3-Benzylnirvanol and (–)-N-3-Benzylnirvanol are potent and selective cytochrome P450 inhibitors with Ki values of 0.25 and 5.3 μM for CYP2C19, respectively. | ||||||||||||||||||||
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(R)-N-3-Benzylnirvanol | (R)-N-3-Benzylnirvanol is the R-isomer of (±)-N-3-Benzylnirvanol (HY-137258). (±)-N-3-Benzylnirvanol is a racemic mixture of (+)-N-3-Benzylnirvanol and (-)-N-3-Benzylnirvanol. (+)-N-3-Benzylnirvanol and (–)-N-3-Benzylnirvanol are potent and selective cytochrome P450 inhibitors with Ki values of 0.25 and 5.3 μM for CYP2C19, respectively. | |||||||||||||||||||||
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5-(4-Hydroxyphenyl)-5-phenyl-d5-hydantoin-2,4,5-13C3 | 5-(4-Hydroxyphenyl)-5-phenyl-d5-hydantoin-2,4,5-13C3 is the deuterium and 13C labeled 5-(4-Hydroxyphenyl)-5-phenyl-hydantoin. | |||||||||||||||||||||
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5-(3-hydroxyphenyl)-5-phenylhydantoin | 5-(3-hydroxyphenyl)-5-phenylhydantoin, is a metabolite of anti-seizure agent Phenytoin. | |||||||||||||||||||||
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Benzil-d10 | Benzil-d10 is the deuterium labeled Benzil. | |||||||||||||||||||||
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Phenytoin sodium (Standard) | 99.94% | Phenytoin (sodium) (Standard) is the analytical standard of Phenytoin (sodium). This product is intended for research and analytical applications. Phenytoin sodium (5,5-Diphenylhydantoin sodium salt) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice. | ||||||||||||||||||||
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Mephenytoin-d5 | 98.72% | Mephenytoin-d5 is the deuterium labeled Mephenytoin. Mephenytoin, an anticonvulsant, is the CYP2C19 and CYP2B6 substrate. | ||||||||||||||||||||
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Benzoin-d10 | Benzoin-d10 (DL-Benzoin-d10) is the deuterium labeled Benzoin (HY-B1550). Benzoin (DL-Benzoin), a natural balsamic resin, is a PI3Kα inhibitor with anticancer effects. Benzoin inihits the growth of colon cancer cell line (HCT-116). Benzoin can be used as a food additive. | |||||||||||||||||||||
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Fosphenytoin | Fosphenytoin is a phosphate ester prodrug of Phenytoin (HY-B0448). Fosphenytoin is used in research related to epileptic seizures. | |||||||||||||||||||||
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Fosphenytoin disodium | 99.91% | Fosphenytoin sodium is a phenytoin proagent with similar anticonvulsant properties. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repetitive firing of action potentials. | ||||||||||||||||||||
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Anthraquinone-d8 | Anthraquinone-d8 is the deuterium labeled Anthraquinone. Anthraquinone is used as a precursor for dye formation. | |||||||||||||||||||||
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(S)-(+)-N-3-Benzylnirvanol | 99.76% | (S)-(+)-N-3-Benzylnirvanol ((+)-N-3-Benzylnirvanol) is a selective and competitive cytochrome P450 (CYP) isoform CYP2C19 inhibitor with a Ki of 250 nM. (S)-(+)-N-3-Benzylnirvanol has low activity against CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2D6, CYP2E1, and CYP3A4. | ||||||||||||||||||||
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N-Nitrosodibenzylamine-d10 | N-Nitrosodibenzylamine-d10 is the deuterium labeled N-Nitrosodibenzylamine (HY-W159870). N-Nitrosodibenzylamine is a potent and orally activity DNA damage inducer. N-Nitrosodibenzylamine induces DNA single-strand breaks (SSBs). | |||||||||||||||||||||
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5-Phenyl-5-(phenyl-d5)imidazolidine-2,4-dione | 5-Phenyl-5-(phenyl-d5)imidazolidine-2,4-dione is deuterium-labeled 5-Phenyl-5-(phenyl-d5)imidazolidine-2,4-dione. | |||||||||||||||||||||
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References
- [1]. Michaela Nelson, et al. The sodium channel-blocking antiepileptic drug phenytoin inhibits breast tumour growth and metastasis. Mol Cancer. 2015 Jan 27;14(1):13. [Content Brief]
- [2]. Rogawski, M.A. and W. Loscher, The neurobiology of antiepileptic drugs. Nat Rev Neurosci, 2004. 5(7): p. 553-64. [Content Brief]
