574-84-5
574-84-5
Chemical Structure
Fraxetin
- CAS No.: 574-84-5
- Formula:C10H8O5
- Molecular Weight:208.17
IUPAC Name: 7,8-dihydroxy-6-methoxy-2H-chromen-2-one
InChIKey: HAVWRBANWNTOJX-UHFFFAOYSA-N
SMILES: O=C1C=CC2=CC(OC)=C(O)C(O)=C2O1
Biological Activity: Fraxetin is isolated from Fraxinus rhynchophylla Hance and has oral bioactivity. Fraxetin has anti-tumor, antibacterial, antioxidant, and anti-inflammatory effects. Fraxetin can induce cell apoptosis[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Fraxetin | 99.96% | Fraxetin is isolated from Fraxinus rhynchophylla Hance and has oral bioactivity. Fraxetin has anti-tumor, antibacterial, antioxidant, and anti-inflammatory effects. Fraxetin can induce cell apoptosis. | ||||||||||||||||||||
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Fraxetin (Standard) | ≥98% | Fraxetin (Standard) is the analytical standard of Fraxetin. This product is intended for research and analytical applications. Fraxetin is isolated from Fraxinus rhynchophylla Hance. Fraxetin has antitumor, anti-oxidation effects and anti-inflammory effects. Fraxetin induces apoptosis. | ||||||||||||||||||||
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Daphnetin (Standard) | ≥98% | Daphnetin (Standard) is the analytical standard of Daphnetin. This product is intended for research and analytical applications. Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC50s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1 , ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research. | ||||||||||||||||||||
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Scopoletin (Standard) | 98.84% | Scopoletin (Standard) is the analytical standard of Scopoletin. This product is intended for research and analytical applications. Scopoletin is an inhibitor of acetylcholinesterase (AChE). | ||||||||||||||||||||
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7-Methoxy-4-methyl-coumarin-8-ol | 99.92% | 7-Methoxy-4-methyl-coumarin-8-ol (compound 31) is a compound isolated from sour orange (Citrus aurantium). | ||||||||||||||||||||
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Isoscopoletin (Standard) | 99.93% | Isoscopoletin (Standard) is the analytical standard of Isoscopoletin. This product is intended for research and analytical applications. Isoscopoletin (6-Hydroxy-7-methoxycoumarin) is an active constituent in Artemisia argyi leaves. Isoscopoletin shows substantial inhibition against cell proliferation, with IC50s of 4.0 μM and 1.6 μM for human CCRF-CEM leukaemia cells and multidrug resistant subline CEM/ADR5000, respectively. Isoscopoletin (6-Hydroxy-7-methoxycoumarin) possesses inhibitory activity against HBV replication. Isoscopoletin exhibits anti-inflammatory activity through inhibition of MAPK/NF-κB/STAT/AKT signaling pathway. | ||||||||||||||||||||
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5-Hydroxy-7-methoxycoumarin | 5-Hydroxy-7-methoxycoumarin is a coumarin compound present in the whole plant of Euphorbia kansuensis, with an IC50 > 40 μM against five human cancer cell lines. | |||||||||||||||||||||
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7,8-Dimethoxycoumarin | 99.75% | 7,8-Dimethoxycoumarin is a coumarin compound derived from Artemisia caruifolia with oral activity. 7,8-Dimethoxycoumarin inhibits mitochondrial permeability transition pore and H+/K+-ATPase, and exhibits antioxidant, anti-inflammatory, renoprotective, neuroprotective and gastroprotective effects. 7,8-Dimethoxycoumarin reduces lipid peroxidation (TBARS), increases GSH levels, inhibits myeloperoxidase (MPO) activity, and regulates the expression of inflammatory factors by inhibiting the NF‑κB and MAPK pathways. 7,8-Dimethoxycoumarin ameliorates gastric mucosal injury, alleviates renal tissue lesions and relieves neuropathic pain. 7,8-Dimethoxycoumarin can be used in studies related to acute renal failure, trigeminal neuralgia and gastritis. | ||||||||||||||||||||
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8-Hydroxy-7-methoxycoumarin | 8-Hydroxy-7-methoxycoumarin is a phenylpropanoid isolated from the calyxes of Physalis alkekengi L. var. franchetii (Mast.) Makino. 8-Hydroxy-7-methoxycoumarin shows cytotoxicity against GLC4 and COLO 320 cancer cell after continuous incubation (4 days) with IC50s of 179 μM and 145 μM. | |||||||||||||||||||||
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4-Methyldaphnetin | 99.40% | 4-Methyldaphnetin is a precursor in the synthesis of derivatives of 4-methyl coumarin. 4-Methyldaphnetin has potent, selective anti-proliferative and apoptosis-inducing effects on several cancer cell lines. 4-Methyldaphnetin possesses radical scavenging property and strongly inhibits membrane lipid peroxidation. | ||||||||||||||||||||
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7-Hydroxy-5-methoxycoumarin | 7-Hydroxy-5-methoxycoumarin is a phloroglucinol-type furocoumarins, a potent naturally-occurring insect antifeedant. | |||||||||||||||||||||
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Hydrangetin | Hydrangetin inhibits platelet aggregation. Hydrangetin can be isolated from Zanthoxylum schinifolium. | |||||||||||||||||||||
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References
- [1]. Liu G, et al. Effect of fraxetin on proliferation and apoptosis in breast cancer cells. Oncol Lett. 2017 Dec;14(6):7374-7378. [Content Brief]
- [2]. Haiting Wang, et al. Antibacterial mechanism of fraxetin against Staphylococcus aureus. Mol Med Rep. 2014 Nov;10(5):2341-5. [Content Brief]
- [3]. Chen X, et al. The therapeutic effect of fraxetin on ethanol-induced hepatic fibrosis by enhancing ethanol metabolism, inhibiting oxidative stress and modulating inflammatory mediators in rats. Int Immunopharmacol. 2018 Mar;56:98-104. [Content Brief]
