596093-98-0
596093-98-0
Chemical Structure
Lepidiline A
- CAS No.: 596093-98-0
- Formula:C19H21ClN2
- Molecular Weight:312.84
IUPAC Name: 1,3-dibenzyl-4,5-dimethyl-1H-imidazol-3-ium chloride
InChIKey: ZATWGHMQWRXUNZ-UHFFFAOYSA-M
SMILES: CC1=C(C)[N+](CC2=CC=CC=C2)=CN1CC3=CC=CC=C3.[Cl-]
Biological Activity: Lepidiline A exhibits cytotoxic activity against HL-60 cells with an IC50 value of 32.3 μM. Lepidiline A targets HSD17B1 activity, increases the bioconversion efficiency of sex hormones (including the conversion of estrogen into 17β-estradiol and 4-androsten-3,7-dione into testosterone), thereby improving the reproductive capacity of fruit flies.[1][2].
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Lepidiline A | 99.54% | Lepidiline A exhibits cytotoxic activity against HL-60 cells with an IC50 value of 32.3 μM. Lepidiline A targets HSD17B1 activity, increases the bioconversion efficiency of sex hormones (including the conversion of estrogen into 17β-estradiol and 4-androsten-3,7-dione into testosterone), thereby improving the reproductive capacity of fruit flies.. | ||||||||||||||||||||
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References
- [1]. Mlostoń G, et al. Synthesis and Cytotoxic Activity of Lepidilines A-D: Comparison with Some 4,5-Diphenyl Analogues and Related Imidazole-2-thiones. J Nat Prod. 2021 Nov 22. [Content Brief]
- [2]. Cheng C, et al. Lepidiline A Improves the Balance of Endogenous Sex Hormones and Increases Fecundity by Targeting HSD17B1. Mol Nutr Food Res. 2020 May;64(10):e1900706. [Content Brief]
