6152-95-0
6152-95-0
Chemical Structure
Pempidine hydrochloride
Synonym(s): 1,2,2,6,6-Pentamethylpiperidine hydrochloride
- CAS 番号: 6152-95-0
- Formula:C10H22ClN
- Molecular Weight:191.74
InChIKey: OEAJJNMBFKSVHF-UHFFFAOYSA-N
SMILES: CC1(C)CCCC(C)(C)N1C.Cl
Biological Activity: Pempidine (1,2,2,6,6-Pentamethylpiperidine) hydrochloride is an orally active ganglionic blocking agent used in the treatment of hypertension. Pempidine hydrochloride blocks the effects of intravenously administered addictive drugs and peripheral vagal nerve stimulation on blood pressure, and reduces the output of acetylcholine[1][2][3].
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Pempidine hydrochloride | Pempidine (1,2,2,6,6-Pentamethylpiperidine) hydrochloride is an orally active ganglionic blocking agent used in the treatment of hypertension. Pempidine hydrochloride blocks the effects of intravenously administered addictive drugs and peripheral vagal nerve stimulation on blood pressure, and reduces the output of acetylcholine. | |||||||||||||||||||||
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References
- [1]. Martin TJ, et al. Pharmacological evaluation of the antagonism of nicotine's central effects by mecamylamine and pempidine. J Pharmacol Exp Ther. 1990 Jul;254(1):45-51. [Content Brief]
- [2]. L. BRETHERICK, Congeners of Pempidine with High Ganglion-blocking Activity. Nature, 1959, 184: 1707-1709 )
- [3]. Haikala, H., & Ahtee, L. (1988). Antagonism of the nicotine-induced changes of the striatal dopamine metabolism in mice by mecamylamine and pempidine. Naunyn-Schmiedeberg's archives of pharmacology, 338(2), 169–173. [Content Brief]
